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TBP and GTF2H4
Number of citations of the paper that reports this interaction (PMID
9159119
)
77
Data Source:
BioGRID
(biochemical, pull down)
TBP
GTF2H4
Gene Name
TATA box binding protein
general transcription factor IIH, polypeptide 4, 52kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Female Pronucleus
Male Pronucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIA Complex
Nuclear Euchromatin
Cytoplasm
Core TFIIH Complex
Nucleoplasm
Holo TFIIH Complex
Molecular Function
RNA Polymerase II Repressing Transcription Factor Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Transcription Regulatory Region DNA Binding
Repressing Transcription Factor Binding
Sequence-specific DNA Binding Transcription Factor Activity
ATP-dependent DNA Helicase Activity
Protein Kinase Activity
Protein Binding
DNA-dependent ATPase Activity
RNA Polymerase II Carboxy-terminal Domain Kinase Activity
Biological Process
Chromatin Silencing At RDNA
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
Transcription From RNA Polymerase III Promoter
Spermatogenesis
Gene Expression
Viral Process
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Nucleotide-excision Repair, DNA Damage Removal
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Phosphorylation
Gene Expression
Viral Process
DNA Duplex Unwinding
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Viral Transcription
Pathways
RNA Polymerase II Promoter Escape
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HIV Infection
RNA Polymerase II Pre-transcription Events
HIV Life Cycle
HIV Transcription Initiation
NoRC negatively regulates rRNA expression
RNA Polymerase II HIV Promoter Escape
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase I Transcription
RNA Polymerase I Transcription Termination
RNA Polymerase I Promoter Escape
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Late Phase of HIV Life Cycle
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase II Transcription Initiation
SIRT1 negatively regulates rRNA Expression
Transcription of the HIV genome
RNA Polymerase II Promoter Escape
Formation of HIV-1 elongation complex containing HIV-1 Tat
Nucleotide Excision Repair
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HIV Infection
Formation of the Early Elongation Complex
Tat-mediated elongation of the HIV-1 transcript
Formation of transcription-coupled NER (TC-NER) repair complex
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
Dual incision reaction in TC-NER
NoRC negatively regulates rRNA expression
HIV Transcription Initiation
HIV Life Cycle
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II HIV Promoter Escape
HIV Transcription Elongation
Dual incision reaction in GG-NER
mRNA Capping
RNA Polymerase I Transcription
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Late Phase of HIV Life Cycle
Formation of RNA Pol II elongation complex
Global Genomic NER (GG-NER)
RNA Polymerase II Transcription Initiation And Promoter Clearance
Transcription-coupled NER (TC-NER)
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of incision complex in GG-NER
RNA Polymerase II Transcription Initiation
Transcription of the HIV genome
RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Type 1 diabetes (
21980299
)
Ulcerative colitis (
20848476
)
Protein-Protein Interactions
113 interactors:
ABT1
AHR
AR
ATF4
BCL3
BRD2
BRF1
BRF2
BTAF1
CAND2
CITED2
COL26A1
CREG1
CREM
CTBP1
CTD
CXXC1
DHX9
DR1
DRAP1
E2F1
EDF1
ELF3
ESR1
FATE1
FOS
FOXF2
GOLGA2
GTF2A1
GTF2A1L
GTF2A2
GTF2B
GTF2E1
GTF2E2
GTF2F1
GTF2F2
GTF2H4
GTF3C2
GTF3C3
GTF3C4
GTF3C5
HAP1
HIST3H3
HMGB1
HNF4A
HNRNPK
HSF1
HTT
IKZF1
JUN
JUND
KDM5A
KLF5
MCM2
MDM2
MSX1
MYC
NACA
NCOA1
NCOA3
NCOA6
NFYB
NFYC
NR3C1
PAX3
PAX5
PAX6
PIAS1
PIAS3
POLR2A
POLR3F
POU2F1
POU2F2
POU3F2
PSMC2
RB1
REL
RELA
REST
RNF4
RUVBL1
RUVBL2
RXRA
SNAPC1
SNAPC2
SNAPC4
SP1
SPI1
SPIB
SSX2IP
SUB1
TAF1
TAF10
TAF11
TAF12
TAF13
TAF15
TAF1A
TAF1B
TAF1C
TAF1L
TAF5
TAF7L
TCF12
TEAD1
TP53
TRAM2
TRIP4
UBE2I
UBTF
WDR62
YWHAE
ZNF76
10 interactors:
ERCC3
ERCC5
GTF2B
GTF2E1
GTF2F1
GTF2H3
POLR2A
TBP
TP53
XBP1P1
Entrez ID
6908
2968
HPRD ID
02511
03456
Ensembl ID
ENSG00000112592
ENSG00000213780
Uniprot IDs
P20226
Q32MN6
Q32MN7
Q92759
PDB IDs
1C9B
1CDW
1JFI
1NVP
1TGH
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Gene Expression
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Cellular Aromatic Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
DNA-templated Transcription, Initiation
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
DNA-templated Transcription, Elongation
Cellular Metabolic Process
Transcription Elongation From RNA Polymerase II Promoter
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Viral Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Process
Metabolic Process
Chromosome Organization
Chromatin Organization
Chromatin Modification
Transcription From RNA Polymerase III Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Modification
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Transcription Elongation From RNA Polymerase II Promoter
DNA-templated Transcription, Elongation
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Viral Process
Transcription From RNA Polymerase II Promoter
Nucleotide-excision Repair
7-methylguanosine MRNA Capping
7-methylguanosine RNA Capping
Transcription-coupled Nucleotide-excision Repair
Positive Regulation Of Viral Transcription
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
Nucleotide-excision Repair, DNA Damage Removal
Transcription, DNA-templated
RNA Biosynthetic Process
Termination Of RNA Polymerase I Transcription
Transcription Elongation From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription From RNA Polymerase I Promoter
Regulation Of Viral Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
DNA Repair
Gene Expression
Nitrogen Compound Metabolic Process
Nucleotide-excision Repair, DNA Incision
Cellular Macromolecule Biosynthetic Process
DNA-templated Transcription, Termination
Negative Regulation Of Gene Expression, Epigenetic
Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
MRNA Processing
UV Protection
Response To UV
DNA Catabolic Process
DNA Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Tagcloud
?
60s
analyzing
cerevisiae
codons
defect
efficiently
encodes
facilitates
fflux
firefly
gfp
homologue
hsp70
inducible
modest
mutant
polysome
polysomes
rarely
saccharomyces
strain
surprisingly
tata
translated
translation
turnover
ydj1
ydj1p
yeast
Tagcloud (Difference)
?
60s
analyzing
cerevisiae
codons
defect
efficiently
encodes
facilitates
fflux
firefly
gfp
homologue
hsp70
inducible
modest
mutant
polysome
polysomes
rarely
saccharomyces
strain
surprisingly
tata
translated
translation
turnover
ydj1
ydj1p
yeast
Tagcloud (Intersection)
?