TBP and MDM2

Number of citations of the paper that reports this interaction (PubMedID 9388200)
0

Data Source:
HPRD (in vitro, in vivo)

		TBP	MDM2
Description		TATA-box binding protein	MDM2 proto-oncogene
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GO Annotations	Cellular Component	Chromatin Euchromatin Male Germ Cell Nucleus Female Germ Cell Nucleus Female Pronucleus Male Pronucleus Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytoplasm Cytosol Protein-containing Complex Pronucleus	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Nuclear Body Transcription Repressor Complex Endocytic Vesicle Membrane Protein-containing Complex Centriolar Satellite Glutamatergic Synapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase III General Transcription Initiation Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding TFIIB-class Transcription Factor Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding 5S RRNA Binding Zinc Ion Binding Transferase Activity Ligase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Receptor Serine/threonine Kinase Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding Ribonucleoprotein Complex Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Disordered Domain Specific Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase III Spermatogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Blood Vessel Development Blood Vessel Remodeling Regulation Of Heart Rate Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Traversing Start Control Point Of Mitotic Cell Cycle Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Iron Ion Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Protein Ubiquitination Protein Sumoylation DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Destabilization Response To Magnesium Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Response To Cocaine Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein-containing Complex Organization Establishment Of Protein Localization Response To Ether Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Response To Steroid Hormone Positive Regulation Of Muscle Cell Differentiation Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Protein Autoubiquitination Cardiac Septum Morphogenesis Protein-containing Complex Assembly Regulation Of Biological Quality Cellular Response To Hydrogen Peroxide Cellular Response To Antibiotic Cellular Response To Vitamin B1 Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To UV-C Signal Transduction By P53 Class Mediator Fibroblast Activation Cellular Response To Actinomycin D Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Formaldehyde Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Amyloid Fibril Formation Response To Water-immersion Restraint Stress Negative Regulation Of Apoptotic Signaling Pathway
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity Signaling by ALK fusions and activated point mutants Degradation of CDH1 NPAS4 regulates expression of target genes
Drugs			Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Penile cancer Alveolar rhabdomyosarcoma Choriocarcinoma Osteosarcoma Glioma
GWAS		Type 1 diabetes ( 21980299)	Pneumoconiosis in silica exposure ( 24986923) Red blood cell count ( 32888494)
Interacting Genes		119 interacting genes: ABT1 AHR AR ATF4 BCL3 BRF1 BRF2 BTAF1 CAND2 CFTR CITED2 COL26A1 CREG1 CREM CTBP1 CTCFL CXXC1 DHX9 DR1 DRAP1 E2F1 EDF1 ELF3 ESR1 ETS1 FATE1 FOS FOXF2 GOLGA2 GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F2 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H3-4 HAP1 HMBOX1 HMGB1 HNF4A HNRNPK HSF1 HTT HUWE1 IKZF1 JUN JUND JUP KDM5A KLF5 MBD2 MCM2 MDM2 MSX1 MYC NACA NCAPH NCOA1 NCOA3 NCOA6 NFE2L2 NFYB NFYC NR3C1 PAX3 PAX5 PAX6 PIAS1 PIAS3 POLR3F POU2F1 POU2F2 POU3F2 PSMC2 RB1 REL RELA REST RNF4 RUVBL1 RUVBL2 RXRA SERPINB5 SNAPC1 SNAPC2 SNAPC4 SP1 SPI1 SPIB SSX2IP SUB1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF1A TAF1B TAF1C TAF1L TAF5 TAF7L TCF12 TEAD1 TP53 TRAM2 TRIP4 UBE2I UBTF WDR62 YEATS2 YWHAE ZNF76	271 interacting genes: ABL1 ABL2 ADRB2 AKAP5 AKT1 ANKRD17 APEX1 APOB APP AR ARRB1 ARRB2 ATF3 ATF4 ATM ATP2A2 ATRX AURKA BAIAP2L1 BRINP1 BTK BTRC CANX CASP2 CASP3 CCAR1 CCDC3 CCNG1 CDC34 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTBP2 CWC25 DAPK1 DAPK3 DAXX DDX24 DDX42 DHFR DLG4 DNAJB4 DYRK2 EGLN3 EID1 EP300 ESR1 EZR F3 FBXO31 FHL2 FKBP1A FOS FOXO1 FOXO3 FOXP3 G3BP2 GADD45A GCAT GLIS2 GNL3 GORAB GRK2 GSK3B GTF2E2 GYS2 H2BC21 H3-4 HCK HDAC1 HEY1 HIF1A HIPK2 HLA-DMB HMGA2 HMGN1 HNRNPK HSP90B1 IER3 IGF1R IL33 IRF1 IRF2 JMY JUN JUND KAT2B KAT5 KIAA1671 KPNA1 LMO7 MAGEA2 MAGEC2 MAP1LC3A MAP2 MAPKAPK2 MAPT MDM4 MED1 MKRN3 MS4A1 MTBP MYC MYD88 MYDGF NACA NAT10 NCL NDUFS1 NGFR NOLC1 NOTCH1 NPIPB3 NPM1 NR1I2 NR3C1 NRON NUCKS1 NUMB OVOL2 PADI4 PAK6 PBX1 PBXIP1 PDCD1 PDE4D PDIA3 PDLIM7 PDS5A PGAM2 PHF7 PHLDB3 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PPP1R10 PRDM2 PRKN PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RAD23A RALY RANBP1 RANBP2 RARA RASSF1 RB1 RBBP6 RBM10 RBM38 RESF1 RIDA RLIM RNF10 RNF115 RNF126 RNF8 RPL11 RPL22 RPL26 RPL36A RPL4 RPL5 RPS23 RPS3 RPS5 RRM2B RRP1 RSL1D1 RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SESN2 SET SETD7 SETDB1 SHPK SIRT2 SIRT3 SMARCA2 SMARCA4 SMARCE1 SMG7 SNCA SORBS2 SRC SREK1 SRSF11 SUMO1 TAF1 TBP TCAP TFIP11 TOP1 TP53 TP53I3 TP53RK TP73 TPR TPT1 TRAF5 TRIB3 TRIM13 TRIM23 TRIM27 TRIM4 TRIM9 TSG101 UBB UBC UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2H UBE2I UBE2J2 UBE2K UBE2L3 UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2Z UBE3A UBQLN4 UBTF USP15 USP2 USP7 VCP VEGFA WRN WT1 XBP1 XIAP XPC YY1AP1 ZNF133 ZNF420
Entrez ID		6908	4193
HPRD ID		02511	01272
Ensembl ID		ENSG00000112592	ENSG00000135679
Uniprot IDs		P20226 Q32MN7	A0A0A8KB75 A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0
PDB IDs		1C9B 1CDW 1JFI 1NVP 1TGH 4ROC 4ROD 4ROE 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5N9G 6MZD 6MZL 6MZM 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGI 7EGJ 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8ITY 8IUE 8IUH 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 9FSO 9FSP 9FSQ 9FSR 9FSS	1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2MPS 2RUH 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4HG7 4JV7 4JV9 4JVE 4JVR 4JWR 4MDN 4MDQ 4OAS 4OBA 4OCC 4ODE 4ODF 4OGN 4OGT 4OGV 4OQ3 4QO4 4QOC 4UD7 4UE1 4UMN 4WT2 4XXB 4ZFI 4ZGK 4ZYC 4ZYF 4ZYI 5AFG 5C5A 5HMH 5HMI 5HMK 5J7F 5J7G 5LAV 5LAW 5LAY 5LAZ 5LN2 5MNJ 5OAI 5OC8 5SWK 5TRF 5UMM 5VK0 5WTS 5XXK 5Z02 5ZXF 6AAW 6GGN 6H22 6HFA 6I29 6I3S 6IM9 6KZU 6Q96 6Q9H 6Q9L 6Q9O 6SQO 6T2D 6T2E 6T2F 6Y4Q 6YR6 7AD0 7AI0 7AI1 7AYE 7BIR 7BIT 7BIV 7BJ0 7BJ6 7BMG 7KJM 7NA1 7NA2 7NA3 7NA4 7NUS 7QDQ 8AEU 8BGU 8EI9 8EIA 8EIB 8EIC 8F0Z 8F10 8F12 8F13 8GCG 8J81 8P0D 8PWC 9GFC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription DNA Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm TBP-class Protein Binding Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process RNA Metabolic Process Chromatin Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Transcription Preinitiation Complex Assembly Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Factor TFIID Complex Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Nucleus Nucleoplasm Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Protein Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Proteolysis Involved In Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process DNA Damage Response Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Signal Transduction By P53 Class Mediator Cytosol Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Response To Stress
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