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RASA1 and APC
Number of citations of the paper that reports this interaction (PubMedID
24412244
)
0
Data Source:
BioGRID
(two hybrid)
RASA1
APC
Description
RAS p21 protein activator 1
APC regulator of Wnt signaling pathway
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Adherens Junction
Bicellular Tight Junction
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Catenin Complex
Lamellipodium
Cell Junction
Beta-catenin Destruction Complex
Leading Edge Membrane
Ruffle Membrane
Cell Projection
Perinuclear Region Of Cytoplasm
Anchoring Junction
Plasma Membrane Bounded Cell Projection
Wnt Signalosome
Molecular Function
Phosphotyrosine Residue Binding
GTPase Activity
GTPase Activator Activity
Signaling Receptor Binding
Protein Binding
Potassium Channel Inhibitor Activity
Enzyme Binding
GTPase Binding
Protein Binding
Beta-catenin Binding
Microtubule Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Gamma-catenin Binding
Cadherin Binding
Microtubule Plus-end Binding
Dynein Complex Binding
Biological Process
Mitotic Cytokinesis
Angiogenesis
Vasculogenesis
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Cell Adhesion
Signal Transduction
Regulation Of Cell Shape
Regulation Of Actin Filament Polymerization
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Ephrin Receptor Signaling Pathway
Blood Vessel Morphogenesis
System Development
Regulation Of RNA Metabolic Process
Regulation Of Intracellular Signal Transduction
Mitotic Cytokinesis
Cell Fate Specification
Heart Valve Development
Endocardial Cushion Morphogenesis
DNA Damage Response
Negative Regulation Of Microtubule Depolymerization
Mitotic Spindle Assembly Checkpoint Signaling
Cell Adhesion
Pattern Specification Process
Nervous System Development
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Wnt Signaling Pathway
Cell Migration
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Regulation Of Microtubule-based Process
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Regulation Of Microtubule-based Movement
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Regulation Of Primary Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Protein Localization To Centrosome
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Downstream signal transduction
EPHB-mediated forward signaling
EPHB-mediated forward signaling
VEGFR2 mediated cell proliferation
Regulation of RAS by GAPs
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Deactivation of the beta-catenin transactivating complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ovarian tumor domain proteases
Drugs
Diseases
RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
Cancer of the anal canal
Familial adenomatous polyposis
Gastric cancer
Esophageal cancer
Gallbladder cancer
GWAS
Chronotype (
30696823
)
Macular thickness (
30535121
)
Major depressive disorder (
23377640
)
Openness (
21173776
)
Prostate cancer aggressiveness (
25939597
)
Type 2 diabetes (
30297969
)
Age at first sexual intercourse (
34211149
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Appendicular lean mass (
33097823
)
Body mass index (
29273807
)
Colorectal cancer or advanced adenoma (
30510241
)
Daytime nap (
33568662
)
Heel bone mineral density (
30598549
)
Reaction time (
29844566
)
Total body bone mineral density (
29304378
)
Interacting Genes
93 interacting genes:
ABL1
AFAP1L2
ANXA6
APC
APP
AR
ARHGAP1
ARHGAP5
AURKA
AURKB
BBS10
BCL10
BCR
BIRC5
BMPR1A
BUB1
CASP3
CASP7
CAV2
CD5
CDKN2A
CSF1R
CSK
DCC
DLC1
DNAJA3
DOK1
DOK2
DOK4
EGFR
EIF1
EPHA2
EPHB2
EPHB3
ERBB2
ERBB3
ERBB4
EZH2
FES
FGFR1
G3BP1
GAB1
GMCL1
GRB2
HCK
HRAS
HSPD1
HTT
IGF1R
INSR
KDR
KHDRBS1
KIT
LCK
LYN
MAGI1
MAP4K4
MET
MLH3
NCK1
NTRK1
OLIG1
PAG1
PDE6D
PDGFRB
PIK3R1
PMS2
PTK2B
PTPRC
PTPRJ
PXN
RAB5A
RACK1
RAP1A
RB1
SERPINA4
SHC1
SLC9A2
SMAD2
SOCS3
SPSB1
SRC
STAU1
STK11
SYK
SYN1
TRMT2A
WWP1
WWP2
XRCC6
YES1
ZAP70
ZNF579
135 interacting genes:
ACTN1
ADGRL1
AGFG1
AGR3
ANKRD17
ANP32B
ANXA7
AP2B1
ARHGEF4
ASAP2
ATOSA
AXIN1
AXIN2
BAAT
BUB1
BUB1B
C4A
CASC3
CCL5
CGNL1
COG4
COG5
CREBBP
CSNK1A1
CSNK1E
CTBP1
CTNNB1
CTSV
CYP17A1
CYTH2
DIRAS3
DKK3
DLG1
DLG3
DLGAP1
DST
EPAS1
ERBIN
EXPH5
FANCC
FBP1
FBXO30
FHOD1
FLNA
GIGYF2
GOLGA2
GSK3B
HGS
HNRNPM
HOXC6
HSPA5
HTRA2
IL24
ING5
IQGAP1
JUP
KIF5B
KIFAP3
KRT13
KRT14
KRT15
KRT17
KRT23
KRT5
LAMA3
LAMA4
MACF1
MAP2K1
MAPRE1
MAPRE2
MBD5
MCM3AP
MKRN1
MT-ND4
MUC1
MYH10
MYH11
MYO6
NANS
NAT2
NAV1
NAV2
NAV3
NCKAP5L
NEB
NOSTRIN
NUP153
NUP214
NUP42
NUP54
NUP58
NUP98
PDLIM2
PKNOX1
PNISR
POM121
POM121C
PPP1R13B
PPP2CA
PPP2R5A
PPP3R2
PRKACA
PSMD1
PTPN13
RANBP9
RASA1
RBM4B
RP1
RPS27
SCRIB
SEC31A
SETDB1
SIAH1
SMAD1
SMC3
SNRNP200
SPECC1L
SPTBN1
SPTBN2
ST14
SYNE1
TAF1
TFAP2A
TFF1
TGFB1
TMEFF1
TMOD1
TPR
TRIM21
TRIM25
TSTD2
TUBA4A
XPO1
ZNF106
ZNF510
Entrez ID
5921
324
HPRD ID
00745
01439
Ensembl ID
ENSG00000145715
ENSG00000134982
Uniprot IDs
P20936
Q59GK3
P25054
R4GMU6
PDB IDs
1WER
1WQ1
2GQI
2GSB
2J05
2J06
2M51
4FSS
6PXB
6PXC
6WAX
6WAY
8BOS
8DGQ
9BZ4
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
4YJE
4YJL
4YK6
5B6G
5IZ6
5IZ8
5IZ9
5IZA
5Z8H
7F6M
7F7O
7XTY
8GSJ
8X2Q
Enriched GO Terms of Interacting Partners
?
Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Protein Kinase Activity
Cell Surface Receptor Signaling Pathway
Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Signal Transduction
ATP Binding
Protein Autophosphorylation
Protein Phosphorylation
Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Phosphorylation
Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Nucleotide Binding
Regulation Of Cell Population Proliferation
Regulation Of Cell Adhesion
SH2 Domain Binding
Positive Regulation Of Cell Migration
Protein Modification Process
Positive Regulation Of Cell Motility
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Locomotion
Developmental Process
Positive Regulation Of Immune System Process
Regulation Of Cell Motility
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Component Biogenesis
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Cell Migration
Receptor Complex
Positive Regulation Of Phosphate Metabolic Process
Positive Regulation Of Cell Population Proliferation
Regulation Of Locomotion
Organelle Organization
Structural Constituent Of Nuclear Pore
Cytoskeleton Organization
Supramolecular Fiber Organization
Cytosol
MRNA Transport
Nuclear Export
Nuclear Pore
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Beta-catenin Destruction Complex
Nuclear Transport
Nucleocytoplasmic Transport
RNA Transport
Nuclear Membrane
RNA Export From Nucleus
Cellular Localization
Cytoskeleton
Intracellular Protein Localization
Regulation Of Nucleocytoplasmic Transport
Intracellular Transport
Nucleobase-containing Compound Transport
Nuclear Localization Sequence Binding
Nuclear Envelope
Establishment Of Localization In Cell
Cadherin Binding
Regulation Of Protein Localization
Actin Filament Binding
Glutamatergic Synapse
Regulation Of Cellular Localization
Protein Export From Nucleus
Hemidesmosome
Intracellular Protein Transport
Actin Binding
Nucleus
Protein Transport
Cellular Component Assembly
Positive Regulation Of Nucleocytoplasmic Transport
Establishment Of Protein Localization
Cytoplasm
Regulation Of Cytoskeleton Organization
Canonical Wnt Signaling Pathway
Regulation Of Intracellular Transport
Structural Molecule Activity
Intermediate Filament Organization
Nuclear Pore Nuclear Basket
Regulation Of Intracellular Protein Transport
Nuclear Pore Organization
Microtubule
Regulation Of Centromeric Sister Chromatid Cohesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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