RASA1 and FGFR1

Number of citations: 45 (PubMedID 8321198)
Data Source: BioGRID (pull down)

		RASA1	FGFR1
Name		RAS p21 protein activator 1	fibroblast growth factor receptor 1
Structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane	Extracellular Region Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Receptor Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity Enzyme Binding GTPase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Fibroblast Growth Factor Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Receptor-receptor Interaction
	Biological Process	Mitotic Cytokinesis Angiogenesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis System Development Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Skeletal System Development Angiogenesis Ureteric Bud Development In Utero Embryonic Development Organ Induction Neuron Migration Epithelial To Mesenchymal Transition Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Protein Phosphorylation Brain Development Salivary Gland Morphogenesis Sensory Perception Of Sound Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Mesenchymal Cell Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Phospholipase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Phosphate Transport Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Cell Projection Assembly Lung Development Embryonic Limb Morphogenesis Midbrain Development Neuron Projection Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Inner Ear Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Ear Development Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Paraxial Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Cell Maturation Blood Vessel Morphogenesis Generation Of Neurons Skeletal System Morphogenesis Mesenchymal Cell Differentiation Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium Ion Homeostasis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Auditory Receptor Cell Development Branching Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Vitamin D3 Metabolic Process Diphosphate Metabolic Process Cementum Mineralization Stem Cell Proliferation Regulation Of Primary Metabolic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production Regulation Of Postsynaptic Density Assembly Positive Regulation Of Mitotic Cell Cycle DNA Replication Response To Sodium Phosphate Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Parathyroid Hormone Secretion Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Signaling by activated point mutants of FGFR1 Signaling by FGFR1 in disease Signaling by plasma membrane FGFR1 fusions Epithelial-Mesenchymal Transition (EMT) during gastrulation Formation of paraxial mesoderm
Drugs		None	Palifermin Sorafenib Heparin 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone XL999 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine (E)-[4-(3,5-Difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE Regorafenib Ponatinib Lenvatinib Nintedanib Tivozanib Infigratinib Fostamatinib Erdafitinib Pemigatinib Futibatinib Selpercatinib Pralsetinib
Diseases		RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)	Hypogonadotropic hypogonadism; Kallmann syndrome (KAL) Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Osteoglophonic dysplasia (OD); Osteoglophonic dwarfism (OGD) Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Chronotype ( 30696823 ) Macular thickness ( 30535121 ) Major depressive disorder ( 23377640 ) Openness ( 21173776 ) Prostate cancer aggressiveness ( 25939597 ) Type 2 diabetes ( 30297969 )	Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Birth weight ( 31043758 ) Body size at age 10 ( 32376654 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) PR interval ( 30046033 32439900 ) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097 ) Schizophrenia ( 29483656 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 32499647 )
Interacting Genes		93 interacting genes: ABL1 AFAP1L2 ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	66 interacting genes: BNIP2 CDH1 CREBBP CRK CTPS2 EPHA4 ERBB2 ERBB3 FBXO7 FDPS FGF1 FGF10 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 HTR1A HULC IL17RD ITGB3 ITK KLB KPNB1 L1CAM LDHA MFHAS1 MMP2 NCAM1 NCK1 NCK2 NECTIN1 NEDD4 NRP1 PDGFRB PDK1 PDP1 PIK3R1 PIK3R2 PKM PLCG1 PTK6 PTPN1 RARA RASA1 RPS6KA1 RTN1 RTN3 SH3BP2 SHC1 SLA SOS1 TNK2 TNS2 VAV1 YES1
Entrez ID		5921	2260
HPRD ID		00745	00634
Ensembl ID		ENSG00000145715	ENSG00000077782
Uniprot IDs		P20936 Q59GK3	A0A0S2Z3Q6 A0A0S2Z3T4 A0A3B3ISD1 A0A8I3B1S4 P11362
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY 8BOS 8DGQ 9BZ4	1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65 4NK9 4NKA 4NKS 4RWI 4RWJ 4RWK 4RWL 4UWB 4UWC 4UWY 4V01 4V04 4V05 4WUN 4ZSA 5A46 5A4C 5AM6 5AM7 5B7V 5EW8 5FLF 5O49 5O4A 5UQ0 5UR1 5VND 5W21 5W59 5Z0S 5ZV2 6C18 6C19 6C1B 6C1C 6C1O 6ITJ 6MZQ 6MZW 6NVL 6P68 6P69 7OZB 7OZD 7OZF 7WCL 7YSH 8JMZ 8JQI 8XLO 8XZ7 8Y22 8YKI 9CD5
GO Terms Enriched among Interactors		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Signal Transduction ATP Binding Protein Autophosphorylation Protein Phosphorylation Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Nucleotide Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion SH2 Domain Binding Positive Regulation Of Cell Migration Protein Modification Process Positive Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Developmental Process Positive Regulation Of Immune System Process Regulation Of Cell Motility Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Migration Receptor Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Population Proliferation Regulation Of ERK1 And ERK2 Cascade Neurogenesis Growth Factor Activity Type 2 Fibroblast Growth Factor Receptor Binding Cell Differentiation Receptor Tyrosine Kinase Binding Cellular Developmental Process Regulation Of Locomotion Regulation Of Cell Migration Neurotrophin TRKA Receptor Binding Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Positive Regulation Of ERK1 And ERK2 Cascade Developmental Process ERBB Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Cell Division Positive Regulation Of Multicellular Organismal Process Angiogenesis Anatomical Structure Morphogenesis Regulation Of Developmental Process Response To Wounding Chemotaxis ErbB-3 Class Receptor Binding Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cytoplasm Regulation Of Anatomical Structure Morphogenesis Locomotion Protein Tyrosine Kinase Activity