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RASA1 and PTK2B
Number of citations of the paper that reports this interaction (PubMedID
10708762
)
0
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology)
HPRD
(in vivo)
RASA1
PTK2B
Description
RAS p21 protein activator 1
protein tyrosine kinase 2 beta
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Cell Cortex
Postsynaptic Density
Membrane
NMDA Selective Glutamate Receptor Complex
Lamellipodium
Cell Junction
Dendrite
Growth Cone
Cell Projection
Neuronal Cell Body
Cell Body
Perinuclear Region Of Cytoplasm
Anchoring Junction
Apical Dendrite
Presynapse
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Phosphotyrosine Residue Binding
GTPase Activity
GTPase Activator Activity
Signaling Receptor Binding
Protein Binding
Potassium Channel Inhibitor Activity
Enzyme Binding
GTPase Binding
Nucleotide Binding
Protein Kinase Activity
Calcium/calmodulin-dependent Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Signaling Receptor Activator Activity
Ionotropic Glutamate Receptor Binding
Neurotransmitter Receptor Regulator Activity
Biological Process
Mitotic Cytokinesis
Angiogenesis
Vasculogenesis
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Cell Adhesion
Signal Transduction
Regulation Of Cell Shape
Regulation Of Actin Filament Polymerization
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Ephrin Receptor Signaling Pathway
Blood Vessel Morphogenesis
System Development
Regulation Of RNA Metabolic Process
Regulation Of Intracellular Signal Transduction
Angiogenesis
Neuron Migration
Regulation Of Cell-matrix Adhesion
Positive Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Adaptive Immune Response
Marginal Zone B Cell Differentiation
Immune System Process
Protein Phosphorylation
Apoptotic Process
Cellular Defense Response
Cytoskeleton Organization
Golgi Organization
Signal Transduction
Cell Surface Receptor Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Positive Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Regulation Of Macrophage Chemotaxis
Positive Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Migration
Negative Regulation Of Bone Mineralization
Positive Regulation Of Actin Filament Polymerization
Cortical Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Tumor Necrosis Factor-mediated Signaling Pathway
Ionotropic Glutamate Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Activation Of Janus Kinase Activity
Negative Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Negative Regulation Of Neuron Apoptotic Process
Bone Resorption
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Regulation Of Multicellular Organismal Process
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synaptic Transmission, Glutamatergic
Long-term Synaptic Potentiation
Protein-containing Complex Assembly
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Fluid Shear Stress
Endothelin Receptor Signaling Pathway
Regulation Of Postsynaptic Density Assembly
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of B Cell Chemotaxis
Pathways
Downstream signal transduction
EPHB-mediated forward signaling
EPHB-mediated forward signaling
VEGFR2 mediated cell proliferation
Regulation of RAS by GAPs
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Signal regulatory protein family interactions
VEGFA-VEGFR2 Pathway
RHOU GTPase cycle
Interleukin-2 signaling
Drugs
Leflunomide
Genistein
4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Fostamatinib
Diseases
RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS
Chronotype (
30696823
)
Macular thickness (
30535121
)
Major depressive disorder (
23377640
)
Openness (
21173776
)
Prostate cancer aggressiveness (
25939597
)
Type 2 diabetes (
30297969
)
Adult body size (
32376654
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
24162737
30617256
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bone mineral content (
31790847
)
Bone mineral density (
31790847
)
Crohn's disease (
26192919
)
Dental caries (
23259602
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Family history of Alzheimer's disease (
30617256
)
Inflammatory bowel disease (
26192919
)
Monocyte count (
32888494
)
Schizophrenia (
29483656
)
Takayasu arteritis (
30498034
25604533
33308445
)
White blood cell count (
32888494
)
Interacting Genes
93 interacting genes:
ABL1
AFAP1L2
ANXA6
APC
APP
AR
ARHGAP1
ARHGAP5
AURKA
AURKB
BBS10
BCL10
BCR
BIRC5
BMPR1A
BUB1
CASP3
CASP7
CAV2
CD5
CDKN2A
CSF1R
CSK
DCC
DLC1
DNAJA3
DOK1
DOK2
DOK4
EGFR
EIF1
EPHA2
EPHB2
EPHB3
ERBB2
ERBB3
ERBB4
EZH2
FES
FGFR1
G3BP1
GAB1
GMCL1
GRB2
HCK
HRAS
HSPD1
HTT
IGF1R
INSR
KDR
KHDRBS1
KIT
LCK
LYN
MAGI1
MAP4K4
MET
MLH3
NCK1
NTRK1
OLIG1
PAG1
PDE6D
PDGFRB
PIK3R1
PMS2
PTK2B
PTPRC
PTPRJ
PXN
RAB5A
RACK1
RAP1A
RB1
SERPINA4
SHC1
SLC9A2
SMAD2
SOCS3
SPSB1
SRC
STAU1
STK11
SYK
SYN1
TRMT2A
WWP1
WWP2
XRCC6
YES1
ZAP70
ZNF579
70 interacting genes:
ARHGAP21
ARHGAP5
ASAP1
ASAP2
BCAR1
CBL
CCR5
CRK
DLG3
DLG4
DLGAP3
EFS
EGFR
ERBB2
ERBB3
EWSR1
FGFR2
FGFR3
FLT1
FYN
GNA13
GRB2
GRIN2A
GSN
IL7R
ITGB2
ITGB3
JAK1
JAK2
JAK3
KCNA2
LCK
LPXN
LYN
MAP3K4
MAP4K4
MAPT
MATK
MCAM
MYH2
NEDD9
NPHP1
PDCD6IP
PDPK1
PIK3R1
PITPNM1
PITPNM2
PITPNM3
PRKCD
PTK2
PTPN11
PTPN12
PTPN6
PXN
RASA1
RB1CC1
SH2D3C
SHC1
SKAP2
SLC2A1
SNCA
SORBS2
SRC
STAP1
STAT3
SYK
TGFB1I1
TLN1
VAV1
ZAP70
Entrez ID
5921
2185
HPRD ID
00745
03131
Ensembl ID
ENSG00000145715
ENSG00000120899
Uniprot IDs
P20936
Q59GK3
Q14289
PDB IDs
1WER
1WQ1
2GQI
2GSB
2J05
2J06
2M51
4FSS
6PXB
6PXC
6WAX
6WAY
8BOS
8DGQ
9BZ4
2LK4
3CC6
3ET7
3FZO
3FZP
3FZR
3FZS
3FZT
3GM1
3GM2
3GM3
3H3C
3U3F
4EKU
4H1J
4H1M
4R32
4XEF
4XEK
4XEV
5TO8
5TOB
6LF3
7PLL
8XOX
8YGX
Enriched GO Terms of Interacting Partners
?
Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Protein Kinase Activity
Cell Surface Receptor Signaling Pathway
Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Signal Transduction
ATP Binding
Protein Autophosphorylation
Protein Phosphorylation
Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Phosphorylation
Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Nucleotide Binding
Regulation Of Cell Population Proliferation
Regulation Of Cell Adhesion
SH2 Domain Binding
Positive Regulation Of Cell Migration
Protein Modification Process
Positive Regulation Of Cell Motility
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Locomotion
Developmental Process
Positive Regulation Of Immune System Process
Regulation Of Cell Motility
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Component Biogenesis
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Cell Migration
Receptor Complex
Positive Regulation Of Phosphate Metabolic Process
Positive Regulation Of Cell Population Proliferation
Regulation Of Locomotion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Focal Adhesion
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Plasma Membrane
Peptidyl-tyrosine Phosphorylation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Cell Adhesion
Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Protein Kinase Activity
Cytosol
Phosphorylation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cytoplasm
Regulation Of Cell Communication
Regulation Of Signaling
Protein Phosphorylation
Positive Regulation Of Cell Adhesion
Cell Activation
Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Intracellular Signal Transduction
Kinase Activity
Growth Hormone Receptor Signaling Pathway
Cell Migration
Leukocyte Activation
Epidermal Growth Factor Receptor Signaling Pathway
Cell-cell Junction
Regulation Of Cell-cell Adhesion
Response To Growth Factor
T Cell Costimulation
Positive Regulation Of MAPK Cascade
Intracellular Signal Transduction
Anchoring Junction
ERBB Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Immune System Process
Cell Motility
Cell Adhesion
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Protein Kinase Binding
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Receptor Tyrosine Kinase Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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