RASA1 and DOK2

Number of citations of the paper that reports this interaction (PMID 10428862)
23

Data Source:
HPRD (in vivo, in vitro)

		RASA1	DOK2
Gene Name		RAS p21 protein activator (GTPase activating protein) 1	docking protein 2, 56kDa
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane	Cytosol
	Molecular Function	Glycoprotein Binding Ras GTPase Activator Activity Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding	Receptor Signaling Protein Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding
	Biological Process	Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Embryo Development Regulation Of Actin Filament Polymerization Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Leukocyte Migration
Pathways		Signaling by PDGF EPHB-mediated forward signaling Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling VEGFA-VEGFR2 Pathway	Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640) Personality dimensions ( 21173776)	Entorhinal cortical thickness ( 21116278) Mean corpuscular volume ( 20139978)
Protein-Protein Interactions		73 interactors: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES G3BP1 GNB2L1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	14 interactors: ABL1 EGFR HCK IL4R INPP5D KIAA1279 LCK LYN NCK1 POT1 RASA1 RET SRC TEK
Entrez ID		5921	9046
HPRD ID		00745	05411
Ensembl ID		ENSG00000145715	ENSG00000147443
Uniprot IDs		B4DTL2 E9PGC0 P20936 Q59GK3	G3V1Q1 O60496
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS	2D9W 2DLW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process ERBB Signaling Pathway Peptidyl-amino Acid Modification Cell Surface Receptor Signaling Pathway Signal Transduction Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Communication Regulation Of Cell Proliferation Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Immune System Process Locomotion Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Phosphorylation Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Immune System Process Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Migration Locomotion Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Protein Autophosphorylation Positive Regulation Of Immune Response Regulation Of Apoptotic Process Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Leukocyte Migration Regulation Of Cell Death Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Regulation Of Cell Proliferation Immune System Process Cell Surface Receptor Signaling Pathway Response To Lipid Immune Response Intracellular Signal Transduction Single Organismal Cell-cell Adhesion Regulation Of Cytokine Secretion Positive Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Peptidyl-amino Acid Modification Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Cellular Response To Lipid Blood Coagulation
Tagcloud ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated	adcy3 angptl2 annotated beadchip bmi boston boys c18orf8 corrected correction cpg epigenomic fdr generational humanmethylation27 illumina infant lends maternal mother offspring plac1 prepregnancy prr16 sapcd2 separately stated wnt16 zcchc10
Tagcloud (Difference) ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated	adcy3 angptl2 annotated beadchip bmi boston boys c18orf8 corrected correction cpg epigenomic fdr generational humanmethylation27 illumina infant lends maternal mother offspring plac1 prepregnancy prr16 sapcd2 separately stated wnt16 zcchc10
Tagcloud (Intersection) ?