RASA1 and MAP4K4

Number of citations: 55 (PubMedID 10669731)
Data Source: HPRD (in vivo)

		RASA1	MAP4K4
Name		RAS p21 protein activator 1	mitogen-activated protein kinase kinase kinase kinase 4
Structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane	Cytoplasm Focal Adhesion
	Molecular Function	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity Enzyme Binding GTPase Binding	Nucleotide Binding Creatine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Mitotic Cytokinesis Angiogenesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis System Development Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of ARF Protein Signal Transduction Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Intracellular Signal Transduction
Pathways		Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Oxidative Stress Induced Senescence
Drugs		None	Fostamatinib
Diseases		RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)	None
GWAS		Chronotype ( 30696823 ) Macular thickness ( 30535121 ) Major depressive disorder ( 23377640 ) Openness ( 21173776 ) Prostate cancer aggressiveness ( 25939597 ) Type 2 diabetes ( 30297969 )	Alzheimer's disease ( 30636644 ) Asthma ( 31619474 ) Asthma (time to onset) ( 27130862 ) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) White blood cell count ( 32888494 )
Interacting Genes		93 interacting genes: ABL1 AFAP1L2 ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	27 interacting genes: BRCA1 CASP8 CTTNBP2NL DOK1 DSCAM GBP3 H2BC21 ITGB1 KIF26B KIF5A LATS1 MAP3K7 MOB4 NCK1 NME7 PPP1CA PPP1CC PPP2CA PRKCE PTK2B RAP2A RASA1 RIPPLY3 SLC9A1 STRIP1 STRN4 TBPL2
Entrez ID		5921	9448
HPRD ID		00745	05235
Ensembl ID		ENSG00000145715	ENSG00000071054
Uniprot IDs		P20936 Q59GK3	B7Z3V5 E7EN19 G5E948 O95819 V9HWH3
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY 8BOS 8DGQ 9BZ4	4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q 8V5I
GO Terms Enriched among Interactors		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Signal Transduction ATP Binding Protein Autophosphorylation Protein Phosphorylation Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Nucleotide Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion SH2 Domain Binding Positive Regulation Of Cell Migration Protein Modification Process Positive Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Developmental Process Positive Regulation Of Immune System Process Regulation Of Cell Motility Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Migration Receptor Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion	FAR/SIN/STRIPAK Complex Regulation Of Hippo Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Hippo Signaling Regulation Of Supramolecular Fiber Organization Cytoplasm Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Regulation Of Actin Filament Length Regulation Of Cellular Component Size RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Perinuclear Region Of Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Lamellipodium Protein Dephosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Glutamatergic Synapse Protein-macromolecule Adaptor Activity Regulation Of Actin Filament-based Process Postsynapse Positive Regulation Of Locomotion Negative Regulation Of Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Cell Communication Regulation Of Organelle Organization Negative Regulation Of Signaling Dephosphorylation PTW/PP1 Phosphatase Complex Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Signaling Receptor Activator Activity Dendritic Spine Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Synapse Organization Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cellular Component Biogenesis Gamma-tubulin Ring Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Locomotion Positive Regulation Of Programmed Cell Death