RASA1 and AFAP1L2

Number of citations of the paper that reports this interaction (PubMedID 17412687)
0

Data Source:
HPRD (in vitro, in vivo)

		RASA1	AFAP1L2
Description		RAS p21 protein activator 1	actin filament associated protein 1 like 2
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity Enzyme Binding GTPase Binding	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity SH2 Domain Binding
	Biological Process	Mitotic Cytokinesis Angiogenesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis System Development Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription
Pathways		Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases		RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)	Cognitive performance ( 20125193) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Systolic blood pressure ( 29212154)
Interacting Genes		93 interacting genes: ABL1 AFAP1L2 ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	10 interacting genes: ACD APP ATXN1L POT1 RASA1 SH3PXD2A SRC TERF1 TERF2 TINF2
Entrez ID		5921	84632
HPRD ID		00745	13902
Ensembl ID		ENSG00000145715	ENSG00000169129
Uniprot IDs		P20936 Q59GK3	A0A8Q3SIY9 B7Z2Q0 Q8N4X5
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY 8BOS 8DGQ 9BZ4	2COF
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Signal Transduction ATP Binding Protein Autophosphorylation Protein Phosphorylation Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Nucleotide Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion SH2 Domain Binding Positive Regulation Of Cell Migration Protein Modification Process Positive Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Developmental Process Positive Regulation Of Immune System Process Regulation Of Cell Motility Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Migration Receptor Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion	Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Telomere Assembly RNA-templated DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Telomere Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization DNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Telomerase Positive Regulation Of DNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Cellular Component Organization Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Chromosome Organization Negative Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Cellular Component Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Protection From Non-homologous End Joining At Telomere Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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