RASA1 and EPHB2

Number of citations of the paper that reports this interaction (PMID 9233798)
61

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RASA1	EPHB2
Gene Name		RAS p21 protein activator (GTPase activating protein) 1	EPH receptor B2
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Glycoprotein Binding Ras GTPase Activator Activity Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding	Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity
	Biological Process	Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Embryo Development Regulation Of Actin Filament Polymerization Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process	Angiogenesis Urogenital System Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Synapse Assembly Palate Development Dendritic Spine Development Dendritic Spine Morphogenesis Commissural Neuron Axon Guidance
Pathways		Signaling by PDGF EPHB-mediated forward signaling Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling VEGFA-VEGFR2 Pathway	EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling L1CAM interactions
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640) Personality dimensions ( 21173776)
Protein-Protein Interactions		73 interactors: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES G3BP1 GNB2L1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	36 interactors: ABL1 ABL2 ACP1 AQP1 ARHGEF6 BCL2 CRK EFNA5 EFNB1 EFNB2 ERF FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MLLT4 MMP2 MMP9 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 VAV2 VEGFA YES1
Entrez ID		5921	2048
HPRD ID		00745	02997
Ensembl ID		ENSG00000145715	ENSG00000133216
Uniprot IDs		B4DTL2 E9PGC0 P20936 Q59GK3	P29323
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS	1B4F 1F0M 2QBX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process ERBB Signaling Pathway Peptidyl-amino Acid Modification Cell Surface Receptor Signaling Pathway Signal Transduction Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Communication Regulation Of Cell Proliferation Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Immune System Process Locomotion Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Phosphorylation Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Immune System Process Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ephrin Receptor Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Neuron Development Cell Projection Morphogenesis Cell Projection Organization Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Neuron Differentiation Cell Morphogenesis Response To External Stimulus Generation Of Neurons Cell Development Neurogenesis Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Signaling Cell Communication Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction System Development Regulation Of Signaling Cellular Response To Stimulus Anatomical Structure Development Multicellular Organismal Development Developmental Process Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cell Migration Regulation Of Phosphorus Metabolic Process
Tagcloud ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Difference) ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Intersection) ?