RASA1 and BCL10

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		RASA1	BCL10
Description		RAS p21 protein activator 1	BCL10 immune signaling adaptor
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane	Immunological Synapse Polkadots Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Membrane CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity Enzyme Binding GTPase Binding	Protease Binding Transcription Coactivator Activity Protein Binding Kinase Activator Activity Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding
	Biological Process	Mitotic Cytokinesis Angiogenesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis System Development Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction	B Cell Apoptotic Process Positive Regulation Of Cytokine Production Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Apoptotic Process Cellular Defense Response Response To Fungus Programmed Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)	Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)
Interacting Genes		93 interacting genes: ABL1 AFAP1L2 ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	45 interacting genes: AKT1 ANP32B ATM BAAT CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NHERF1 NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1
Entrez ID		5921	8915
HPRD ID		00745	04625
Ensembl ID		ENSG00000145715	ENSG00000142867
Uniprot IDs		P20936 Q59GK3	A0A087WWW9 A2TDT2 O95999
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY 8BOS 8DGQ 9BZ4	2MB9 6BZE 6GK2 8CZD 8CZO
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Signal Transduction ATP Binding Protein Autophosphorylation Protein Phosphorylation Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Nucleotide Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion SH2 Domain Binding Positive Regulation Of Cell Migration Protein Modification Process Positive Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Developmental Process Positive Regulation Of Immune System Process Regulation Of Cell Motility Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Migration Receptor Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion	Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Modification Process CBM Complex Regulation Of Signal Transduction CARD Domain Binding Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of Signaling Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Pattern Recognition Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-2 Production Non-canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Process
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