RASA1 and ERBB3

Number of citations of the paper that reports this interaction (PMID 16273093)
170

Data Source:
BioGRID (unspecified method)

		RASA1	ERBB3
Gene Name		RAS p21 protein activator (GTPase activating protein) 1	erb-b2 receptor tyrosine kinase 3
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Receptor Complex
	Molecular Function	Glycoprotein Binding Ras GTPase Activator Activity Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding	Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Embryo Development Regulation Of Actin Filament Polymerization Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process	Endocardial Cushion Development Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Schwann Cell Differentiation Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cranial Nerve Development Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Protein Tyrosine Kinase Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by PDGF EPHB-mediated forward signaling Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640) Personality dimensions ( 21173776)	Obesity-related traits ( 23251661) Type 1 diabetes ( 19430480 18198356 17554260 17554300 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22951725)
Protein-Protein Interactions		73 interactors: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES G3BP1 GNB2L1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	66 interactors: ABL1 ABL2 AGTR2 BCAR3 CD82 CDK5 CHN2 CRK CRKL DAB1 DAPP1 EGF EGFR EGR1 ERBB2 ERBB4 FER FGFR1 FLNA FLYWCH1 GRB2 GRB7 HCK HDAC6 IL6ST ITK JAK2 JAK3 MUC1 NCK1 NCK2 NEDD4 NRG1 NRG2 ODF2L PA2G4 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTGES3 PTK2 PTK2B PTK6 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 SH2B3 SH2D1A SHC1 SHC3 SOS1 SRC SYK TNS2 TNS3 TNS4 TXK VAV1 VAV2 VAV3 ZAP70 ZNF207
Entrez ID		5921	2065
HPRD ID		00745	01820
Ensembl ID		ENSG00000145715	ENSG00000065361
Uniprot IDs		B4DTL2 E9PGC0 P20936 Q59GK3	P21860
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS	1M6B 2L9U 3KEX 3LMG 3P11 4LEO
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process ERBB Signaling Pathway Peptidyl-amino Acid Modification Cell Surface Receptor Signaling Pathway Signal Transduction Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Communication Regulation Of Cell Proliferation Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Immune System Process Locomotion Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Phosphorylation Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Immune System Process Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Cell Communication Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Signaling Regulation Of Signaling Cell Migration Signal Transduction Immune Response Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Cell Motility Locomotion Positive Regulation Of Signal Transduction Regulation Of Immune System Process Intracellular Signal Transduction Defense Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Fc-epsilon Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Cell Activation Response To Growth Factor Response To Stress Positive Regulation Of Catalytic Activity Response To Stimulus Wound Healing Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Blood Coagulation Hemostasis
Tagcloud ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Difference) ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Intersection) ?