AURKA and TP73

Number of citations of the paper that reports this interaction (PMID 22340593)
7

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, affinity chromatography technology)

		AURKA	TP73
Gene Name		aurora kinase A	tumor protein p73
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Nucleus Centrosome Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Spindle Pole Centrosome Chromosome Passenger Complex Germinal Vesicle Axon Hillock Pronucleus Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle Meiotic Spindle	Chromatin Nucleus Nucleoplasm Transcription Factor Complex Golgi Apparatus Cytosol Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Serine Kinase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Mitotic Nuclear Division Mitotic Centrosome Separation Anterior/posterior Axis Specification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Histone-serine Phosphorylation Negative Regulation Of Apoptotic Process Spindle Stabilization Positive Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Cycle Protein Autophosphorylation Cell Division Centrosome Localization Protein Localization To Centrosome Negative Regulation Of Spindle Checkpoint Positive Regulation Of Oocyte Maturation Neuron Projection Extension	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Transcription From RNA Polymerase II Promoter Inflammatory Response Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To X-ray Response To Organonitrogen Compound Response To Gamma Radiation Regulation Of Gene Expression Hippocampus Development Mitotic G1 DNA Damage Checkpoint Cerebrospinal Fluid Secretion Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of mitotic cell cycle G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic
Drugs		Phosphonothreonine Adenosine-5\'-Diphosphate 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4\',3\':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
Diseases
GWAS			Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738)
Protein-Protein Interactions		54 interactors: APP ARPC1B ARPC2 AURKAIP1 BIRC5 BORA BRCA1 CBX3 CDC20 CDC25B CHFR CKAP5 CSN2 GADD45A GMNN GSK3B HDAC2 HDAC6 HIST3H3 IKBKB INCENP KIF11 KIF2C MAPRE2 MAPRE3 MBD3 MDM2 NDC80 NFKBIA NIN NME1 NUF2 PLK3 PML PPP1CA PPP1CB PPP1CC PRKACA PTTG1 PUM2 RASSF1 SRPK1 SRPK2 SUMO1 TACC1 TACC3 TLK1 TLK2 TP53 TP73 TPX2 UBE2N USP2 VHL	50 interactors: ABL1 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP DAXX EP300 FBXO45 GNB2L1 HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PML PPP1R13B RANBP9 RBX1 RCHY1 SMAD2 SMAD3 SUMO1 TDG TP53 TP63 UBE2I WT1 WWOX XPO1 YAP1
Entrez ID		6790	7161
HPRD ID		04066	03587
Ensembl ID		ENSG00000087586	ENSG00000078900
Uniprot IDs		O14965	C9J521 O15350
PDB IDs		1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 4B0G 4DEA 4DEB 4DED 4DEE 4DHF 4JAI 4JAJ 4JBO 4JBP 4JBQ	1COK 1DXS 2KBY 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUQ
Enriched GO Terms of Interacting Partners?		Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Cell Cycle Cell Division Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Radiation Entrainment Of Circadian Clock By Photoperiod Regulation Of Organelle Organization Regulation Of Proteolysis Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Cellular Protein Modification Process Chromosome Segregation Negative Regulation Of Biosynthetic Process Response To Stress Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Cell Cycle Checkpoint Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Regulation Of Cell Death Response To Light Stimulus Cellular Protein Metabolic Process Circadian Rhythm Response To Growth Factor Regulation Of Apoptotic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Negative Regulation Of Catalytic Activity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Cellular Component Organization	Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Apoptotic Process Programmed Cell Death Negative Regulation Of Cell Cycle Cell Cycle Process Regulation Of Signal Transduction Cell Death Cellular Response To Stress Death Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 threonine waf1 wortmannin	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Difference) ?		adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 threonine waf1 wortmannin	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Intersection) ?