AURKA and PTTG1

Number of citations of the paper that reports this interaction (PMID 19117984)
1

Data Source:
BioGRID (pull down)

		AURKA	PTTG1
Gene Name		aurora kinase A	pituitary tumor-transforming 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Nucleus Centrosome Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Spindle Pole Centrosome Chromosome Passenger Complex Germinal Vesicle Axon Hillock Pronucleus Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle Meiotic Spindle	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Serine Kinase Activity	Sequence-specific DNA Binding Transcription Factor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Mitotic Nuclear Division Mitotic Centrosome Separation Anterior/posterior Axis Specification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Histone-serine Phosphorylation Negative Regulation Of Apoptotic Process Spindle Stabilization Positive Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Cycle Protein Autophosphorylation Cell Division Centrosome Localization Protein Localization To Centrosome Negative Regulation Of Spindle Checkpoint Positive Regulation Of Oocyte Maturation Neuron Projection Extension	Mitotic Cell Cycle DNA Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Chromosome Segregation Mitotic Nuclear Division Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Division
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of mitotic cell cycle G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins
Drugs		Phosphonothreonine Adenosine-5\'-Diphosphate 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4\',3\':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
Diseases
GWAS			Insulin-related traits ( 22791750) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		54 interactors: APP ARPC1B ARPC2 AURKAIP1 BIRC5 BORA BRCA1 CBX3 CDC20 CDC25B CHFR CKAP5 CSN2 GADD45A GMNN GSK3B HDAC2 HDAC6 HIST3H3 IKBKB INCENP KIF11 KIF2C MAPRE2 MAPRE3 MBD3 MDM2 NDC80 NFKBIA NIN NME1 NUF2 PLK3 PML PPP1CA PPP1CB PPP1CC PRKACA PTTG1 PUM2 RASSF1 SRPK1 SRPK2 SUMO1 TACC1 TACC3 TLK1 TLK2 TP53 TP73 TPX2 UBE2N USP2 VHL	15 interactors: ANAPC11 AURKA CAMK2A CDC20 CDC27 CDK1 CUL1 DNAJA1 FZR1 PPP2R5A PTTG1IP RPS10 TP53 UBE4A XRCC6
Entrez ID		6790	9232
HPRD ID		04066	04998
Ensembl ID		ENSG00000087586	ENSG00000164611
Uniprot IDs		O14965	O95997 Q6IAL9
PDB IDs		1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 4B0G 4DEA 4DEB 4DED 4DEE 4DHF 4JAI 4JAJ 4JBO 4JBP 4JBQ
Enriched GO Terms of Interacting Partners?		Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Cell Cycle Cell Division Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Radiation Entrainment Of Circadian Clock By Photoperiod Regulation Of Organelle Organization Regulation Of Proteolysis Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Cellular Protein Modification Process Chromosome Segregation Negative Regulation Of Biosynthetic Process Response To Stress Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Cell Cycle Checkpoint Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Regulation Of Cell Death Response To Light Stimulus Cellular Protein Metabolic Process Circadian Rhythm Response To Growth Factor Regulation Of Apoptotic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Negative Regulation Of Catalytic Activity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Cellular Component Organization	Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Mitotic Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Cycle Process Cell Cycle Checkpoint Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Catabolic Process Regulation Of Cell Cycle Process Protein K11-linked Ubiquitination Regulation Of Cell Division
Tagcloud ?		adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 threonine waf1 wortmannin	coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley
Tagcloud (Difference) ?		adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 threonine waf1 wortmannin	coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley
Tagcloud (Intersection) ?