AURKA and CDH13

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		AURKA	CDH13
Description		aurora kinase A	cadherin 13
Image
GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Basolateral Plasma Membrane Midbody Spindle Pole Centrosome Chromosome Passenger Complex Ciliary Basal Body Germinal Vesicle Cell Projection Neuron Projection Axon Hillock Pronucleus Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle Meiotic Spindle Mitotic Spindle Pole Glutamatergic Synapse	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Caveola Adherens Junction Focal Adhesion External Side Of Plasma Membrane Membrane Catenin Complex Extracellular Matrix Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Side Of Membrane GABA-ergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone H3S10 Kinase Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Molecular Function Activator Activity	Calcium Ion Binding Protein Binding Beta-catenin Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Cadherin Binding Metal Ion Binding Adiponectin Binding Lipoprotein Particle Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Chromatin Remodeling Protein Phosphorylation Apoptotic Process Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Centrosome Cycle Mitotic Centrosome Separation Response To Wounding Anterior/posterior Axis Specification Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Peptidyl-serine Phosphorylation Cell Projection Organization Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Regulation Of Microtubule-based Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Regulation Of Centrosome Cycle Protein Autophosphorylation Cell Division Meiotic Cell Cycle Centrosome Localization Cilium Disassembly Protein Localization To Centrosome Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitochondrial Fission Liver Regeneration Positive Regulation Of Oocyte Maturation Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Extension	Cell Morphogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Rac Protein Signal Transduction Lamellipodium Assembly Regulation Of Endocytosis Positive Regulation Of Cell Migration Adherens Junction Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelial Cell Migration Keratinocyte Proliferation Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Positive Chemotaxis Regulation Of Transport Localization Within Membrane Low-density Lipoprotein Particle Mediated Signaling Cellular Response To Xenobiotic Stimulus Cellular Response To Toxic Substance Cell-cell Adhesion
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of PLK1 Activity at G2/M Transition SUMOylation of DNA replication proteins TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation FBXL7 down-regulates AURKA during mitotic entry and in early mitosis AURKA Activation by TPX2 Interaction between PHLDA1 and AURKA	Adherens junctions interactions
Drugs		Phosphonothreonine AT9283 CYC116 Alisertib SNS-314 Cenisertib Enzastaurin 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE AKI-001 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE Fostamatinib MK-5108 MLN8054
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Adiponectin levels ( 31178129 20876611 20887962 21771975 22065538 22479202 24105470) Adolescent idiopathic scoliosis ( 30395268 31417091) Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Alcohol consumption (heavy vs. light/non-drinkers) ( 27911795) Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756) Blood pressure ( 17903302) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Crohn's disease ( 28067908) D-dimer levels ( 21502573) Daytime sleep phenotypes ( 27126917) Declining hemoglobin trajectory in blood donors ( 33491795) Dental caries (decayed, missing and filled teeth) ( 31533690) Depression (quantitative trait) ( 20800221) Diastolic blood pressure ( 27841878 31170924 30578418) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erectile dysfunction ( 30583798) Feeling hurt ( 29500382) Feeling tense ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Gait speed in old age ( 28077804) General risk tolerance (MTAG) ( 30643258) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (Blautia) ( 33208821) Gut microbiota relative abundance (Prevotella) ( 33208821) Height ( 20189936) Hippocampal volume ( 31530798) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Hypertension ( 19304780) Hypothyroidism ( 27182965) IgE levels in asthmatics (D.f. specific) ( 23967269) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Leukoderma in response to rhododendrol ( 32558222) Maximal oxygen uptake response ( 25729143) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Oily fish consumption ( 32066663) Periodontitis (Mean PAL) ( 24024966) Pork consumption ( 32066663) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Precuneus cortex volume ( 31530798) Pulse pressure ( 30578418 28739976 28135244 27841878) Rapid automised naming of digits ( 30741946) Refractive astigmatism ( 30306274) Response to amphetamines ( 22952603) Response to antipsychotic treatment ( 20195266) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (adiponectin levels) ( 23149075) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Schizophrenia ( 23358160) Seasonality and depression ( 30217971) Short-term memory (digit-span task) ( 30741946)
Interacting Genes		171 interacting genes: AATF AJUBA AKT1 ANGPTL4 ANP32B APP ARPC1B ARPC2 ATRX AUNIP AURKAIP1 BAAT BCL2L1 BEX2 BIRC5 BLID BORA BRAF BRCA1 BTK CBX3 CCND2 CCNE1 CDC20 CDC25B CDH13 CDK8 CEBPA CHFR CKAP5 CORO2A CPEB1 CSN2 CTCFL CYLC2 DACH1 DKK3 EHMT2 EPHA2 EPSTI1 ERBB2 ERRFI1 FANCA FBP2 FOXF1 FOXP1 GADD45A GMNN GSK3B GTF3C4 H3-4 H3C1 HDAC2 HEMGN HIF1A HNRNPF HNRNPK IFI16 IGFBP3 IKBKB KIF11 KIF2C KLHL18 KLK5 LATS2 LEF1 LYPD3 MAP2K1 MAP2K3 MAP3K5 MAPK3 MAPRE2 MAPRE3 MBD3 MBP MDM2 MED26 MTA3 MYC MYT1 MYT1L NANS NAT2 NDC80 NEDD9 NF2 NFKBIA NFXL1 NIN NKX1-1 NME1 NSD2 NUF2 OLA1 OTUB1 PARP10 PAX4 PAX8 PDGFRA PDLIM2 PLK3 PML POU4F3 PPP1CA PPP1CB PPP1CC PPP3R2 PPP6C PRKACA PSEN2 PSMC3IP PSRC1 PTPRD PTTG1 PUM2 RASA1 RASSF1 RELA REST S100A14 SCGB3A1 SEC61B SFRP4 SIN3B SOX18 SOX3 SOX30 SOX4 SREBF2 SRPK1 SRPK2 SSRP1 STAT2 STK11 STX17 SUPT20H SWT1 TACC1 TACC3 TBC1D2 TBX10 TCEAL2 TCERG1 TCF3 TEAD2 TFAP2B TGFB1 THRSP TLK1 TLK2 TP53 TP73 TPX2 TRMO TRRAP TSC1 TSTD2 UBE2C UBE2I UBE2N UBTF USP2 USP21 VHL WIF1 XPA YY1 ZFHX3 ZKSCAN2 ZNF189 ZNF510	12 interacting genes: ADIPOQ ANXA1 AURKA CASP8 CCND1 CHEK2 HMMR MAPK6 MTNR1B PTPN1 RAD51 SNCA
Entrez ID		6790	1012
HPRD ID		04066	03219
Ensembl ID		ENSG00000087586	ENSG00000140945
Uniprot IDs		O14965	B7Z3H7 B7Z9B1 P55290
PDB IDs		1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 3W10 3W16 3W18 3W2C 4B0G 4BN1 4BYI 4BYJ 4C3P 4C3R 4CEG 4DEA 4DEB 4DED 4DEE 4DHF 4J8M 4J8N 4JAI 4JAJ 4JBO 4JBP 4JBQ 4O0S 4O0U 4O0W 4PRJ 4UYN 4UZD 4UZH 4ZS0 4ZTQ 4ZTR 4ZTS 5AAD 5AAE 5AAF 5AAG 5DN3 5DNR 5DOS 5DPV 5DR2 5DR6 5DR9 5DRD 5DT0 5DT3 5DT4 5EW9 5G15 5G1X 5L8J 5L8K 5L8L 5LXM 5OBJ 5OBR 5ODT 5ONE 5ORL 5ORN 5ORO 5ORP 5ORR 5ORS 5ORT 5ORV 5ORW 5ORX 5ORY 5ORZ 5OS0 5OS1 5OS2 5OS3 5OS4 5OS5 5OS6 5OSD 5OSE 5OSF 5ZAN 6C2R 6C2T 6C83 6CPE 6CPF 6CPG 6GRA 6HJJ 6HJK 6I2U 6R49 6R4A 6R4B 6R4C 6R4D 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA 6Z4Y 7AYH 7AYI 7FIC 7O2V 7ZTL 8C14 8C15 8C1D 8C1E 8C1F 8C1G 8C1H 8C1I 8C1K 8C1M 8GUW 8JF4 8JG8 8JMX 8OF5 8PR7 8SSO 8SSP 9BZG 9BZL	2V37
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Intracellular Signal Transduction Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Cell Division Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Population Proliferation Chromatin Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Radiation Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Stress Cytoplasm Regulation Of Signal Transduction Anatomical Structure Morphogenesis	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Response To Xenobiotic Stimulus Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Protein-containing Complex Regulation Of Cell Cycle Phase Transition Protein Kinase Binding Response To Glycoside Negative Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Cell Cycle Process Regulation Of Neuron Apoptotic Process Response To Alcohol Response To Stress Cellular Response To Epinephrine Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Epinephrine Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Response To Ethanol Response To Magnesium Ion Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Biological Quality Regulation Of Cell Cycle Process Positive Regulation Of Vesicle Fusion Negative Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Cell Cycle Response To Glucocorticoid Negative Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Regulation Of DNA Damage Checkpoint Response To Ionizing Radiation Enzyme Binding Positive Regulation Of Developmental Process Response To Lipid Regulation Of Intracellular Signal Transduction Regulation Of Macrophage Differentiation Mitotic Cell Cycle Phase Transition Regulation Of Inflammatory Response Response To Corticosteroid Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Defense Response Response To X-ray Negative Regulation Of Transport
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