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AURKA and BCL2L1
Number of citations of the paper that reports this interaction (PubMedID
22617334
)
46
Data Source:
BioGRID
(enzymatic study)
AURKA
BCL2L1
Description
aurora kinase A
BCL2 like 1
Image
GO Annotations
Cellular Component
Kinetochore
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Centriole
Microtubule Organizing Center
Spindle
Cytosol
Cytoskeleton
Microtubule
Spindle Microtubule
Plasma Membrane
Cilium
Postsynaptic Density
Microtubule Cytoskeleton
Membrane
Basolateral Plasma Membrane
Midbody
Spindle Pole Centrosome
Chromosome Passenger Complex
Ciliary Basal Body
Germinal Vesicle
Cell Projection
Neuron Projection
Axon Hillock
Pronucleus
Perinuclear Region Of Cytoplasm
Spindle Midzone
Mitotic Spindle
Meiotic Spindle
Mitotic Spindle Pole
Glutamatergic Synapse
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Endoplasmic Reticulum
Centrosome
Cytosol
Cytoskeleton
Membrane
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Nuclear Membrane
Mitochondrial Membrane
Synapse
Bcl-2 Family Protein Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Histone H3S10 Kinase Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Molecular Function Activator Activity
Protein Binding
Channel Activity
Protein Kinase Binding
Identical Protein Binding
BH3 Domain Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Meiotic Spindle Organization
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Chromatin Remodeling
Protein Phosphorylation
Apoptotic Process
Spindle Organization
Mitotic Spindle Organization
Spindle Assembly Involved In Female Meiosis I
Centrosome Cycle
Mitotic Centrosome Separation
Response To Wounding
Anterior/posterior Axis Specification
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Peptidyl-serine Phosphorylation
Cell Projection Organization
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Regulation Of Microtubule-based Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cell Cycle G2/M Phase Transition
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Centrosome Cycle
Protein Autophosphorylation
Cell Division
Meiotic Cell Cycle
Centrosome Localization
Cilium Disassembly
Protein Localization To Centrosome
Positive Regulation Of Cell Cycle Process
Positive Regulation Of Mitochondrial Fission
Liver Regeneration
Positive Regulation Of Oocyte Maturation
Regulation Of Signal Transduction By P53 Class Mediator
Neuron Projection Extension
Ovarian Follicle Development
In Utero Embryonic Development
Release Of Cytochrome C From Mitochondria
Endocytosis
Apoptotic Process
Response To Stress
Mitochondrion Organization
Germ Cell Development
Spermatogenesis
Male Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Apoptotic Mitochondrial Changes
Response To Radiation
Fertilization
Response To Virus
Negative Regulation Of Autophagy
Regulation Of Cytokinesis
Positive Regulation Of Mononuclear Cell Proliferation
Response To Cytokine
Ectopic Germ Cell Programmed Cell Death
Regulation Of Growth
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Dendritic Cell Proliferation
Response To Cycloheximide
Regulation Of Mitochondrial Membrane Permeability
Epithelial Cell Proliferation
Negative Regulation Of Developmental Process
Neuron Apoptotic Process
Defense Response To Virus
Response To Other Organism
Regulation Of Mitochondrial Membrane Potential
Transmembrane Transport
Cellular Response To Amino Acid Stimulus
Cellular Response To Alkaloid
Cellular Response To Gamma Radiation
Apoptotic Process In Bone Marrow Cell
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Dendritic Cell Apoptotic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Hepatocyte Apoptotic Process
Negative Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Reproductive Process
Negative Regulation Of Dendritic Cell Apoptotic Process
Negative Regulation Of Anoikis
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
SUMOylation of DNA replication proteins
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
AURKA Activation by TPX2
Interaction between PHLDA1 and AURKA
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-4 and Interleukin-13 signaling
The NLRP1 inflammasome
RAS processing
SARS-CoV-1-mediated effects on programmed cell death
STAT5 activation downstream of FLT3 ITD mutants
NFE2L2 regulating tumorigenic genes
Drugs
Phosphonothreonine
AT9283
CYC116
Alisertib
SNS-314
Cenisertib
Enzastaurin
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
AKI-001
1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea
1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea
N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE
N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide
2-(1H-pyrazol-3-yl)-1H-benzimidazole
N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
Fostamatinib
MK-5108
MLN8054
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
Gossypol
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Brain morphology (MOSTest) (
32665545
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
27863252
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder (
26184070
)
Platelet count (
27863252
32888494
)
Plateletcrit (
27863252
32888494
)
Prudent dietary pattern (
28644415
)
Putamen volume (
29147026
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
171 interacting genes:
AATF
AJUBA
AKT1
ANGPTL4
ANP32B
APP
ARPC1B
ARPC2
ATRX
AUNIP
AURKAIP1
BAAT
BCL2L1
BEX2
BIRC5
BLID
BORA
BRAF
BRCA1
BTK
CBX3
CCND2
CCNE1
CDC20
CDC25B
CDH13
CDK8
CEBPA
CHFR
CKAP5
CORO2A
CPEB1
CSN2
CTCFL
CYLC2
DACH1
DKK3
EHMT2
EPHA2
EPSTI1
ERBB2
ERRFI1
FANCA
FBP2
FOXF1
FOXP1
GADD45A
GMNN
GSK3B
GTF3C4
H3-4
H3C1
HDAC2
HEMGN
HIF1A
HNRNPF
HNRNPK
IFI16
IGFBP3
IKBKB
KIF11
KIF2C
KLHL18
KLK5
LATS2
LEF1
LYPD3
MAP2K1
MAP2K3
MAP3K5
MAPK3
MAPRE2
MAPRE3
MBD3
MBP
MDM2
MED26
MTA3
MYC
MYT1
MYT1L
NANS
NAT2
NDC80
NEDD9
NF2
NFKBIA
NFXL1
NIN
NKX1-1
NME1
NSD2
NUF2
OLA1
OTUB1
PARP10
PAX4
PAX8
PDGFRA
PDLIM2
PLK3
PML
POU4F3
PPP1CA
PPP1CB
PPP1CC
PPP3R2
PPP6C
PRKACA
PSEN2
PSMC3IP
PSRC1
PTPRD
PTTG1
PUM2
RASA1
RASSF1
RELA
REST
S100A14
SCGB3A1
SEC61B
SFRP4
SIN3B
SOX18
SOX3
SOX30
SOX4
SREBF2
SRPK1
SRPK2
SSRP1
STAT2
STK11
STX17
SUPT20H
SWT1
TACC1
TACC3
TBC1D2
TBX10
TCEAL2
TCERG1
TCF3
TEAD2
TFAP2B
TGFB1
THRSP
TLK1
TLK2
TP53
TP73
TPX2
TRMO
TRRAP
TSC1
TSTD2
UBE2C
UBE2I
UBE2N
UBTF
USP2
USP21
VHL
WIF1
XPA
YY1
ZFHX3
ZKSCAN2
ZNF189
ZNF510
111 interacting genes:
ACTB
AKT1
ANTXR1
APAF1
AURKA
AVEN
BAD
BAG1
BAK1
BAX
BBC3
BCAP31
BCL2
BCL2L10
BCL2L11
BCL2L12
BCL2L14
BCLAF1
BECN1
BID
BIK
BLK
BMF
BNIP1
BNIP3
BNIP3L
BNIP5
BNIPL
C10orf67
CAPN1
CASP1
CASP8
CASP9
CDKN2A
CFLAR
CHEK1
CREB3
CRYAA
CRYAB
CYCS
DOCK7
EDRF1
ELOVL4
ERGIC3
FBP1
FKBP8
G0S2
GLOD4
GNLY
GOLM1
GORAB
GSK3A
GSK3B
HNRNPA1
HRK
IKZF3
IRS1
IRS2
LARP1
MAPK14
MAPK8
MAPK9
MAPKAPK2
MCL1
METTL23
MOAP1
MTIF3
MTNR1B
MTOR
NLRP1
PARK7
PDIA4
PINK1
PLD3
PLK1
PLK3
PMAIP1
PPHLN1
PPP1CA
PRKN
PSEN1
PSEN2
PTN
RAD9A
RAF1
RBM5
REEP4
RHBDD2
RIC3
RNF183
RNF4
RTN1
RTN4
RYR3
SIVA1
SNCA
SPNS1
TLE1
TMBIM6
TMEM50B
TP53
TP53BP2
TPT1
UBE2I
UBR1
UHRF2
VAC14
VDAC1
ZFYVE1
ZHX1
ZNF219
Entrez ID
6790
598
HPRD ID
04066
02497
Ensembl ID
ENSG00000087586
ENSG00000171552
Uniprot IDs
O14965
A0A0S2Z3C5
Q07817
Q5TE63
PDB IDs
1MQ4
1MUO
1OL5
1OL6
1OL7
2BMC
2C6D
2C6E
2DWB
2J4Z
2J50
2NP8
2W1C
2W1D
2W1E
2W1F
2W1G
2WQE
2WTV
2WTW
2X6D
2X6E
2X81
2XNE
2XNG
2XRU
3COH
3E5A
3EFW
3FDN
3H0Y
3H0Z
3H10
3HA6
3K5U
3LAU
3M11
3MYG
3NRM
3O50
3O51
3P9J
3QBN
3R21
3R22
3UNZ
3UO4
3UO5
3UO6
3UOD
3UOH
3UOJ
3UOK
3UOL
3UP2
3UP7
3VAP
3W10
3W16
3W18
3W2C
4B0G
4BN1
4BYI
4BYJ
4C3P
4C3R
4CEG
4DEA
4DEB
4DED
4DEE
4DHF
4J8M
4J8N
4JAI
4JAJ
4JBO
4JBP
4JBQ
4O0S
4O0U
4O0W
4PRJ
4UYN
4UZD
4UZH
4ZS0
4ZTQ
4ZTR
4ZTS
5AAD
5AAE
5AAF
5AAG
5DN3
5DNR
5DOS
5DPV
5DR2
5DR6
5DR9
5DRD
5DT0
5DT3
5DT4
5EW9
5G15
5G1X
5L8J
5L8K
5L8L
5LXM
5OBJ
5OBR
5ODT
5ONE
5ORL
5ORN
5ORO
5ORP
5ORR
5ORS
5ORT
5ORV
5ORW
5ORX
5ORY
5ORZ
5OS0
5OS1
5OS2
5OS3
5OS4
5OS5
5OS6
5OSD
5OSE
5OSF
5ZAN
6C2R
6C2T
6C83
6CPE
6CPF
6CPG
6GRA
6HJJ
6HJK
6I2U
6R49
6R4A
6R4B
6R4C
6R4D
6VPG
6VPH
6VPI
6VPJ
6VPL
6VPM
6XKA
6Z4Y
7AYH
7AYI
7FIC
7O2V
7ZTL
8C14
8C15
8C1D
8C1E
8C1F
8C1G
8C1H
8C1I
8C1K
8C1M
8GUW
8JF4
8JG8
8JMX
8OF5
8PR7
8SSO
8SSP
9BZG
9BZL
1BXL
1G5J
1LXL
1MAZ
1R2D
1R2E
1R2G
1R2H
1R2I
1YSG
1YSI
1YSN
2B48
2LP8
2LPC
2M03
2M04
2ME8
2ME9
2MEJ
2O1Y
2O2M
2O2N
2P1L
2PON
2YJ1
2YQ6
2YQ7
2YXJ
3CVA
3FDL
3FDM
3INQ
3IO8
3PL7
3QKD
3R85
3SP7
3SPF
3WIZ
3ZK6
3ZLN
3ZLO
3ZLR
4A1U
4A1W
4AQ3
4BPK
4C52
4C5D
4CIN
4EHR
4HNJ
4IEH
4PPI
4QVE
4QVF
4QVX
4TUH
4Z9V
5AGW
5AGX
5B1Z
5C3G
5FMJ
5FMK
5VAY
5VX3
6BF2
6DCN
6DCO
6F46
6HJL
6IJQ
6LHD
6O0K
6O0L
6O0M
6O0O
6O0P
6RNU
6ST2
6UVC
6UVD
6UVE
6UVF
6UVG
6UVH
6VWC
6X7I
6YLI
6ZHC
7CA4
7JGV
7JGW
7LH7
7XGF
7XGG
7Y8D
7YAA
8FY0
8IQK
8IQL
8U27
8VWX
8VWZ
8VXM
8VXN
8WLS
8XP5
8ZEB
9AQZ
Enriched GO Terms of Interacting Partners
?
Nucleus
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Intracellular Signal Transduction
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Cell Division
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Differentiation
Regulation Of Developmental Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Population Proliferation
Chromatin
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Response To Radiation
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of Cellular Component Organization
DNA-binding Transcription Factor Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Response To Stress
Cytoplasm
Regulation Of Signal Transduction
Anatomical Structure Morphogenesis
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Programmed Cell Death
Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Cellular Response To Stress
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Programmed Cell Death
Regulation Of Mitochondrion Organization
Negative Regulation Of Apoptotic Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Apoptotic Mitochondrial Changes
Mitochondrion Organization
Mitochondrial Outer Membrane
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Response To Stress
Mitochondrion
Regulation Of Cellular Response To Stress
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Membrane Permeability
Regulation Of Mitochondrial Membrane Permeability
Extrinsic Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Regulation Of Autophagy
Mitochondrial Membrane Organization
Positive Regulation Of Mitochondrial Membrane Permeability
Positive Regulation Of Organelle Organization
Regulation Of Signal Transduction
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Membrane Permeability
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Bcl-2 Family Protein Complex
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Mitochondrial Membrane Potential
Regulation Of Signaling
Regulation Of Cell Communication
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Response To Decreased Oxygen Levels
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Protein-containing Complex Assembly
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