AURKA and KIF2C

Number of citations of the paper that reports this interaction (PMID 18434591)
33

Data Source:
BioGRID (enzymatic study)

		AURKA	KIF2C
Gene Name		aurora kinase A	kinesin family member 2C
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Nucleus Centrosome Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Spindle Pole Centrosome Chromosome Passenger Complex Germinal Vesicle Axon Hillock Pronucleus Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle Meiotic Spindle	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Nucleus Cytosol Kinesin Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane Microtubule Plus-end
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Serine Kinase Activity	Microtubule Motor Activity Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Microtubule Plus-end Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Mitotic Nuclear Division Mitotic Centrosome Separation Anterior/posterior Axis Specification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Histone-serine Phosphorylation Negative Regulation Of Apoptotic Process Spindle Stabilization Positive Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Cycle Protein Autophosphorylation Cell Division Centrosome Localization Protein Localization To Centrosome Negative Regulation Of Spindle Checkpoint Positive Regulation Of Oocyte Maturation Neuron Projection Extension	Mitotic Cell Cycle Microtubule-based Movement Microtubule Depolymerization Mitotic Nuclear Division Mitotic Metaphase Plate Congression Blood Coagulation Metabolic Process Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Cell Division Regulation Of Chromosome Segregation
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of mitotic cell cycle G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic	Mitotic Prometaphase Separation of Sister Chromatids Kinesins Mitotic Anaphase Factors involved in megakaryocyte development and platelet production M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion MHC class II antigen presentation Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs		Phosphonothreonine Adenosine-5\'-Diphosphate 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4\',3\':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
Diseases
GWAS
Protein-Protein Interactions		54 interactors: APP ARPC1B ARPC2 AURKAIP1 BIRC5 BORA BRCA1 CBX3 CDC20 CDC25B CHFR CKAP5 CSN2 GADD45A GMNN GSK3B HDAC2 HDAC6 HIST3H3 IKBKB INCENP KIF11 KIF2C MAPRE2 MAPRE3 MBD3 MDM2 NDC80 NFKBIA NIN NME1 NUF2 PLK3 PML PPP1CA PPP1CB PPP1CC PRKACA PTTG1 PUM2 RASSF1 SRPK1 SRPK2 SUMO1 TACC1 TACC3 TLK1 TLK2 TP53 TP73 TPX2 UBE2N USP2 VHL	8 interactors: APP AURKA CENPH CSNK2B HIST3H3 MAPRE1 VHL ZNF566
Entrez ID		6790	11004
HPRD ID		04066	05172
Ensembl ID		ENSG00000087586	ENSG00000142945
Uniprot IDs		O14965	B7Z6Q6 Q99661
PDB IDs		1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 4B0G 4DEA 4DEB 4DED 4DEE 4DHF 4JAI 4JAJ 4JBO 4JBP 4JBQ	2HEH
Enriched GO Terms of Interacting Partners?		Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Cell Cycle Cell Division Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Radiation Entrainment Of Circadian Clock By Photoperiod Regulation Of Organelle Organization Regulation Of Proteolysis Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Cellular Protein Modification Process Chromosome Segregation Negative Regulation Of Biosynthetic Process Response To Stress Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Cell Cycle Checkpoint Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Regulation Of Cell Death Response To Light Stimulus Cellular Protein Metabolic Process Circadian Rhythm Response To Growth Factor Regulation Of Apoptotic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Negative Regulation Of Catalytic Activity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Cellular Component Organization	Regulation Of Binding Regulation Of Protein Binding Protein Localization To Cytoskeleton Mitotic Cell Cycle Negative Regulation Of Microtubule Polymerization Or Depolymerization Cell Morphogenesis Regulation Of Microtubule Polymerization Or Depolymerization Developmental Cell Growth Negative Regulation Of Spindle Checkpoint Posttranscriptional Regulation Of Gene Expression Cell Cycle Spindle Assembly Involved In Female Meiosis I Synaptic Growth At Neuromuscular Junction Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Stability Developmental Growth Involved In Morphogenesis Neuron Projection Morphogenesis Spindle Assembly Involved In Meiosis Collateral Sprouting In Absence Of Injury Positive Regulation Of Microtubule Plus-end Binding Regulation Of Microtubule Cytoskeleton Organization Cell Growth Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Spindle Stabilization Regulation Of Microtubule-based Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Projection Development Cellular Component Assembly Cell Projection Morphogenesis Axon Choice Point Recognition Cell Part Morphogenesis Positive Regulation Of Cell Cycle Process Positive Regulation Of Oocyte Maturation Positive Regulation Of Activin Receptor Signaling Pathway Protein Localization To Microtubule Adiponectin-activated Signaling Pathway Meiotic Spindle Organization Protein Localization To Centrosome Neuron Remodeling Mitotic Centrosome Separation Neuron Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Female Meiosis I Developmental Growth Positive Regulation Of Oocyte Development
Tagcloud ?		adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 threonine waf1 wortmannin	acquisition bioinformatics blocking catastrophe chemoresistance chemoresistant chemosensitive chip clinicopathological contributes deregulation documented establish foxm1 immunohistochemistry implicated invasion knockdown migration mitotic multivariate ovarian paclitaxel prognostic qpcr shorter silencing targets tumorigenesis
Tagcloud (Difference) ?		adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing killing kip1 mitochondria monophosphate n78 nci orally phosphatidylinositol proapoptotic proautophagic responds sb202191 threonine waf1 wortmannin	acquisition bioinformatics blocking catastrophe chemoresistance chemoresistant chemosensitive chip clinicopathological contributes deregulation documented establish foxm1 immunohistochemistry implicated invasion knockdown migration mitotic multivariate ovarian paclitaxel prognostic qpcr shorter silencing targets tumorigenesis
Tagcloud (Intersection) ?