ZFP36L1 and ACD

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		ZFP36L1	ACD
Description		ZFP36 ring finger protein like 1	ACD shelterin complex subunit and telomerase recruitment factor
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding 14-3-3 Protein Binding	DNA Binding Protein Binding Telomerase Inhibitor Activity Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Vasculogenesis Proepicardium Development MRNA Processing Regulation Of Translation Apoptotic Process Heart Development Cell Population Proliferation Response To Wounding Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Neural Tube Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of MRNA 3'-end Processing Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Multicellular Organism Growth P38MAPK Cascade Regulation Of MRNA Stability Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Monocyte Differentiation Regulation Of Myoblast Differentiation Mesendoderm Development Embryonic Organ Development MRNA Transport Chorio-allantoic Fusion 3'-UTR-mediated MRNA Destabilization ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Stem Cell Proliferation Cellular Response To Raffinose Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intracellular MRNA Localization	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Segmentation Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Telomere
Pathways		Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 31959851) Blond vs. brown/black hair color ( 30531825) Celiac disease ( 22057235 20190752 25920553) Crohn's disease ( 21102463) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure ( 30224653) Fibrinogen levels ( 26561523 28107422) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 31511532) Multiple sclerosis ( 24076602 21833088) Nonsyndromic cleft lip ( 31609978) Prostate cancer ( 23535732) Rheumatoid arthritis ( 32723749) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		9 interacting genes: ACD AKT1 MAPK14 MAPKAPK2 PAFAH1B2 POT1 TERF1 TINF2 YWHAB	64 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FBXW7 FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790
Entrez ID		677	65057
HPRD ID		03041	12417
Ensembl ID		ENSG00000185650	ENSG00000102977
Uniprot IDs		B3KNA8 Q07352	A0A8Q3WM11 Q96AP0
PDB IDs		1W0V 1W0W	2I46 5H65 5I2X 5I2Y 5UN7 5XYF 7QXA 7QXB 7QXS 7S1T 7TRE 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomerase Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Metabolic Process RNA-templated DNA Biosynthetic Process Regulation Of Telomere Maintenance Cellular Response To Vascular Endothelial Growth Factor Stimulus Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Protein Serine/threonine Kinase Activity Chromosome, Telomeric Region Regulation Of Establishment Of Protein Localization To Telomere Regulation Of DNA Metabolic Process Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Metabolic Process Regulation Of Chromosome Organization Telomeric D-loop Disassembly RNA Stabilization G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region DNA Biosynthetic Process Negative Regulation Of RNA Catabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Cytoplasm Cytosol Cadherin Binding Carbohydrate Catabolic Process Nuclear Telomere Cap Complex Protein Folding Chaperone Complex Substantia Nigra Development ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Glycolytic Process Telomere Maintenance Cellular Response To Heat ADP Metabolic Process Nicotinamide Nucleotide Metabolic Process Nucleoside Diphosphate Catabolic Process Monosaccharide Metabolic Process Ribonucleoside Diphosphate Catabolic Process Unfolded Protein Binding Telomeric D-loop Binding Telomere Assembly Organelle Organization Neural Nucleus Development Pyruvate Metabolic Process Glucose Metabolic Process Telomere Organization Protein Folding Cortical Cytoskeleton Glucose Catabolic Process Telomeric DNA Binding Protein Binding Shelterin Complex Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Cytoskeleton Microtubule Cytoskeleton Organization Nucleoside Diphosphate Metabolic Process Protein Stabilization Chaperone-mediated Autophagy Microtubule Response To Heat Purine Nucleotide Catabolic Process Nitric-oxide Synthase Regulator Activity TPR Domain Binding Hexose Metabolic Process Microtubule Cytoskeleton Intercellular Bridge Telomeric D-loop Disassembly Hsp90 Protein Binding
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