ZFP36L1 and PAFAH1B2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZFP36L1	PAFAH1B2
Gene Name		ZFP36 ring finger protein-like 1	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Nucleolus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity MRNA Binding Protein Binding Poly(A) RNA Binding Metal Ion Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Vasculogenesis Proepicardium Development Regulation Of Transcription, DNA-templated Regulation Of Translation Apoptotic Process Heart Development Cell Proliferation Gene Expression Neural Tube Development T Cell Differentiation In Thymus Multicellular Organism Growth Regulation Of MRNA Stability Chorio-allantoic Fusion Spongiotrophoblast Layer Development	Lipid Metabolic Process Spermatogenesis Brain Development Lipid Catabolic Process Positive Regulation Of Macroautophagy
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Prostate cancer ( 23535732)	Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		9 interactors: ACD AKT1 MAPK14 MAPKAPK2 PAFAH1B2 POT1 TERF1 TINF2 YWHAB	14 interactors: ACIN1 ASF1A CCT3 PAFAH1B1 PAFAH1B3 PARK2 PINX1 PPP1R12C REXO1 RPLP0 SLA SNUPN TIMM50 ZFP36L1
Entrez ID		677	5049
HPRD ID		03041	03940
Ensembl ID		ENSG00000185650	ENSG00000168092
Uniprot IDs		B3KNA8 Q07352	P68402
PDB IDs		1W0V 1W0W	1VYH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Replication Telomere Maintenance Positive Regulation Of Transferase Activity Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA Replication Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Telomere Maintenance Peptidyl-serine Phosphorylation Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of DNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process MRNA Stabilization Response To Growth Factor Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of MAPK Cascade	Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Organelle Negative Regulation Of JNK Cascade MRNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SnRNA Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Cellular Localization RNA Import Into Nucleus Positive Regulation Of Protein Linear Polyubiquitination Proepicardium Development Regulation Of Cytokine-mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Targeting Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Establishment Of Centrosome Localization Adult Locomotory Behavior Catabolic Process Neuromuscular Process Cellular Component Assembly Protein Localization Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Chromosome Condensation Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Platelet Activating Factor Metabolic Process Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell Single Organism Reproductive Process Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of MAPK Cascade MRNA Catabolic Process Regulation Of JNK Cascade Adult Behavior Positive Regulation Of Monocyte Differentiation
Tagcloud ?		antisense ccr4 deadenylase destabilization detailed disruption dissociation erk identifying ldlr lipoprotein oligonucleotide oligonucleotides p90 possibly potency proteomic recruit ribosomal rnas s6 stabilization stabilized therapeutics unstable untranslated usefulness utr	1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Difference) ?		antisense ccr4 deadenylase destabilization detailed disruption dissociation erk identifying ldlr lipoprotein oligonucleotide oligonucleotides p90 possibly potency proteomic recruit ribosomal rnas s6 stabilization stabilized therapeutics unstable untranslated usefulness utr	1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Intersection) ?