CDC34 and ROCK1

Number of citations of the paper that reports this interaction (PubMedID 16123592)
0

Data Source:
HPRD (in vitro)

		CDC34	ROCK1
Description		cell division cycle 34, ubiquitin conjugating enzyme	Rho associated coiled-coil containing protein kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Golgi Membrane Ruffle Extracellular Region Cytoplasm Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Stress Granule Membrane Lamellipodium Bleb Secretory Granule Lumen Cell Projection Schaffer Collateral - CA1 Synapse
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Small GTPase Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination	Mitotic Cytokinesis Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Apical Constriction Apoptotic Process Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Neuron Projection Development Bleb Assembly Negative Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Keratinocyte Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Phosphate Metabolic Process Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Negative Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Regulation Of Microtubule Cytoskeleton Organization Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Regulation Of Synapse Maturation Podocyte Cell Migration Motor Neuron Apoptotic Process Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Neuron Projection Arborization Positive Regulation Of Amyloid-beta Clearance Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cell Junction Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Apoptotic cleavage of cellular proteins EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOH GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS RND3 GTPase cycle
Drugs			Hydroxyfasudil (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE Fasudil Y-27632 Ripasudil Netarsudil Belumosudil
Diseases
GWAS			Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Lysophosphatidylcholine levels ( 31551469) Telomere length ( 30185882)
Interacting Genes		60 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 DIABLO EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PTTG1 RAG1 RBX1 RELA RNF167 RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM13 TRIM21 TRIM28 TRIM29 UBB UBC UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1	40 interacting genes: ADD1 ARHGAP24 CASP3 CASP7 CDC25A CDC34 CFAP206 CRMP1 DES DPYSL2 EZR FAM124A GFAP HMGB2 IKBKB IRS1 ITSN2 LIMK1 LIMK2 LINC00452 LMO2 MAGEB4 MLC1 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOB RHOC RND3 SMAD2 SMAD5 TPPP TRIM15 TSG101 UBE2T VIM
Entrez ID		997	6093
HPRD ID		00306	03414
Ensembl ID		ENSG00000099804	ENSG00000067900
Uniprot IDs		P49427	Q13464
PDB IDs		2OB4 3RZ3 4MDK 7M2K 8RX0	1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S 4L2W 4W7P 4YVC 4YVE 5BML 5F5P 5HVU 5KKS 5KKT 5UZJ 5WNE 5WNF 5WNG 5WNH 6E9W 7JOU 7S25 7S26 8P0S 8ZH5
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Macromolecule Catabolic Process Protein Polyubiquitination Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Protein Destabilization Regulation Of Protein Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Autophagy Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction	Focal Adhesion Cytoskeleton Supramolecular Fiber Organization Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cytoplasm Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Astral Microtubule Organization Regulation Of Actin Filament-based Process Actin Filament Organization Positive Regulation Of Protein Localization To Endosome Negative Regulation Of Cell Projection Organization Regulation Of Protein-containing Complex Assembly Skeletal Muscle Satellite Cell Migration Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Establishment Of Epithelial Cell Apical/basal Polarity Protein Kinase Binding Regulation Of Establishment Of Endothelial Barrier Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Actin Filament Bundle Assembly Actin Filament Bundle Assembly Cytoplasmic Microtubule Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Actin Filament Bundle Organization Actin Cytoskeleton Organization Developmental Process Establishment Of Apical/basal Cell Polarity Regulation Of Cell Projection Organization Intracellular Signaling Cassette Polarized Epithelial Cell Differentiation Cytoskeletal Protein Binding Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cellular Component Size Regulation Of Organelle Assembly Negative Regulation Of Cellular Component Organization Regulation Of Actin Filament Organization Cellular Developmental Process Cellular Response To Staurosporine Cell Differentiation Actin Filament-based Process Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Polarity Regulation Of Adherens Junction Organization
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