CDC34 and FBXO4

Number of citations of the paper that reports this interaction (PubMedID 10531035)
0

Data Source:
BioGRID (enzymatic study)

		CDC34	FBXO4
Description		cell division cycle 34, ubiquitin conjugating enzyme	F-box protein 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Ubiquitin Ligase Complex Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination	Protein Polyubiquitination Telomere Maintenance Cytoplasmic Translational Initiation Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Cellular Homeostasis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Telomere Maintenance Via Telomerase Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Translation Negative Regulation Of Fibroblast Proliferation Cellular Response To Ionizing Radiation Cellular Senescence Membraneless Organelle Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Polyubiquitination Regulation Of DNA Damage Checkpoint
Pathways		Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes		60 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 DIABLO EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PTTG1 RAG1 RBX1 RELA RNF167 RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM13 TRIM21 TRIM28 TRIM29 UBB UBC UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1	9 interacting genes: CCND1 CDC34 ELF4 HNRNPK SKP1 TERF1 TNNI3K UBE2D2 UBE2D3
Entrez ID		997	26272
HPRD ID		00306	09949
Ensembl ID		ENSG00000099804	ENSG00000151876
Uniprot IDs		P49427	B3KNA0 D6RAJ6 Q9UKT5
PDB IDs		2OB4 3RZ3 4MDK 7M2K 8RX0	3L2O 3L82 9JKB
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Macromolecule Catabolic Process Protein Polyubiquitination Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Protein Destabilization Regulation Of Protein Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Autophagy Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction	Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Nucleoplasm Nucleus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Monoubiquitination Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Post-translational Protein Modification Protein Autoubiquitination Protein Modification Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Macromolecule Catabolic Process Proteasomal Protein Catabolic Process NK T Cell Proliferation F-box Domain Binding Bundle Of His Cell To Purkinje Myocyte Communication Re-entry Into Mitotic Cell Cycle Positive Regulation Of Low-density Lipoprotein Particle Clearance Cul7-RING Ubiquitin Ligase Complex Proteolysis Mitotic Cell Cycle Phase Transition Natural Killer Cell Proliferation Peptidyl-serine Autophosphorylation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Biosynthetic Process Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Protein Catabolic Process Response To Vitamin E Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Ankyrin Repeat Binding
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