CDC34 and MARCHF1

Number of citations of the paper that reports this interaction (PubMedID 14722266)
36

Data Source:
BioGRID (pull down)

		CDC34	MARCHF1
Description		cell division cycle 34, ubiquitin conjugating enzyme	membrane associated ring-CH-type finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Trans-Golgi Network Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity MHC Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination	Protein Polyubiquitination Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Protein Ubiquitination
Pathways		Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		60 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 DIABLO EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PTTG1 RAG1 RBX1 RELA RNF167 RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM13 TRIM21 TRIM28 TRIM29 UBB UBC UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1	7 interacting genes: CDC34 HLA-DRA HLA-DRB1 INSR UBC UBE2D1 UBE2H
Entrez ID		997	55016
HPRD ID		00306	07940
Ensembl ID		ENSG00000099804	ENSG00000145416
Uniprot IDs		P49427	A8K0Z6 D6RGC4 Q8TCQ1
PDB IDs		2OB4 3RZ3 4MDK 7M2K 8RX0
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Macromolecule Catabolic Process Protein Polyubiquitination Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Protein Destabilization Regulation Of Protein Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Autophagy Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction	Ubiquitin Conjugating Enzyme Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Myeloid Dendritic Cell Antigen Processing And Presentation Dendritic Cell Antigen Processing And Presentation Endocytic Vesicle Membrane Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane Positive Regulation Of Memory T Cell Differentiation MHC Class II Receptor Activity Protein K48-linked Ubiquitination Regulation Of Memory T Cell Differentiation T Cell Receptor Binding Polysaccharide Binding Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Positive Regulation Of Regulatory T Cell Differentiation MHC Class II Protein Complex Binding Modification-dependent Protein Catabolic Process Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Endogenous Antigen Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding Regulation Of Regulatory T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Proteolysis Involved In Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Regulation Of T Cell Mediated Cytotoxicity Immunological Synapse Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Protein Polyubiquitination Regulation Of T-helper Cell Differentiation Transport Vesicle Membrane Positive Regulation Of Alpha-beta T Cell Differentiation ER To Golgi Transport Vesicle Membrane Protein Modification Process Post-translational Protein Modification Antigen Processing And Presentation Of Peptide Antigen Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of T Cell Mediated Immunity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?