SAMHD1 and TIRAP

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		SAMHD1	TIRAP
Gene Name		SAM domain and HD domain 1	toll-interleukin 1 receptor (TIR) domain containing adaptor protein
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Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Plasma Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Ruffle Membrane Intercellular Bridge
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding DGTPase Activity DGTP Binding	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Binding, Bridging Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	DGTP Catabolic Process Immune Response Cytokine-mediated Signaling Pathway Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Type I Interferon Signaling Pathway	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP FBXO25 RBX1 TIRAP	25 interactors: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK1 IRAK2 IRAK4 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1
Entrez ID		25939	114609
HPRD ID		08418	05878
Ensembl ID		ENSG00000101347	ENSG00000150455
Uniprot IDs		Q59H15 Q9Y3Z3	P58753
PDB IDs		2E8O 3U1N	2Y92 3UB2 3UB3 3UB4 4FZ5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Notch Signaling Pathway Regulation Of Protein Binding Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Synaptic Growth At Neuromuscular Junction Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Collateral Sprouting In Absence Of Injury Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Binding Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Axon Choice Point Recognition Neuron Remodeling Positive Regulation Of Protein Homodimerization Activity Protein Neddylation 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Positive Regulation Of Toll-like Receptor Signaling Pathway Posttranscriptional Regulation Of Gene Expression Cellular Response To Lipoteichoic Acid Positive Regulation Of Interleukin-6 Biosynthetic Process Cellular Copper Ion Homeostasis Regulation Of Protein Homodimerization Activity Protein Ubiquitination Regulation Of Interleukin-6 Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Protein Modification By Small Protein Conjugation Regulation Of Growth Positive Regulation Of Neutrophil Chemotaxis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Granulocyte Chemotaxis MRNA Stabilization Negative Regulation Of Growth Of Symbiont In Host Regulation Of Neutrophil Chemotaxis Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Neutrophil Migration Positive Regulation Of Interleukin-8 Production Mating Behavior Regulation Of Signal Transduction Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Granulocyte Chemotaxis	Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Immune Response Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Biotic Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Defense Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Other Organism Positive Regulation Of Innate Immune Response Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune Response Response To Organic Substance Cellular Response To Organic Substance Regulation Of Chemokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Response To Stress Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process Response To External Stimulus Cell Communication Response To Molecule Of Bacterial Origin TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 serpin serpinb6 tymp wars	7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr
Tagcloud (Difference) ?		cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 serpin serpinb6 tymp wars	7kch arpe19 atherosclerosis autooxidation chamber cholesterol deposits efflux esters eye implants inductions inserted instead involve ketocholesterol lipoprotein macular myd88 oxidized robust rsks seem seems suspected tlr4 tram trif upr
Tagcloud (Intersection) ?