SAMHD1 and FAM13B

Number of citations of the paper that reports this interaction (PubMedID 25423367)
0

Data Source:
BioGRID (two hybrid)

		SAMHD1	FAM13B
Description		SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	family with sequence similarity 13 member B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain	Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Catalytic Activity RNA Nuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Hydrolase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding Metal Ion Binding Deoxynucleoside Triphosphate Hydrolase Activity	GTPase Activator Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Immune System Process DGTP Catabolic Process DNA Replication DNA Repair Immune Response DNA Damage Response Deoxyribonucleotide Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Innate Immune Response Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway DNA Strand Resection Involved In Replication Fork Processing	Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Nucleotide catabolism Interferon alpha/beta signaling	CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases		Aicardi-Goutieres Syndrome (AGS)
GWAS		Caffeine consumption from coffee or tea ( 33287642) Height ( 28552196)	Atrial fibrillation ( 28416818 29892015 30061737) Autism spectrum disorder or schizophrenia ( 28540026) Plateletcrit ( 32888494)
Interacting Genes		15 interacting genes: ACTB APP ARAP3 CDK1 CHUK DYSF FAM13B FBXO25 FBXO7 IKBKB NONO SUMO2 TIRAP TRIM21 USP7	8 interacting genes: AGTR1 CDC42 LINC00839 RAC1 SAMHD1 YWHAE YWHAG YWHAZ
Entrez ID		25939	51306
HPRD ID		08418	06464
Ensembl ID		ENSG00000101347	ENSG00000031003
Uniprot IDs		A0A2R8YCS7 Q59H15 Q9Y3Z3	A0A2X0SG06 A0A8I5KSB9 Q9NYF5
PDB IDs		2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM 7A5Y 7LTT 7LU5 7S2Y 7UJN 8D94 8D9J 8GB1 8GB2 8QXJ 8QXK 8QXL 8QXM 8QXN 8QXO 8TDV 8TDW 9EC2
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response IkappaB Kinase Activity Post-translational Protein Modification Regulation Of Cellular Component Organization Innate Immune Response CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Transferrin Receptor Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Activation Of Innate Immune Response IkappaB Kinase Complex Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Positive Regulation Of Defense Response Defense Response To Other Organism Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Catabolic Process Regulation Of Circadian Rhythm Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Immune Response Immune System Process Regulation Of Type I Interferon Production Protein Ubiquitination Protein Heterodimerization Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Immune System Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Response To Copper Ion Regulation Of Proteolysis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex Immune Response	Focal Adhesion Protein Sequestering Activity Phosphoserine Residue Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Establishment Of Golgi Localization Thioesterase Binding Melanosome Golgi Localization Intracellular Signaling Cassette Angiotensin-activated Signaling Pathway GTP-dependent Protein Binding Intracellular Signal Transduction Positive Regulation Of Lamellipodium Assembly Phagocytosis, Engulfment Negative Regulation Of Immune System Process Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Targeting Negative Regulation Of Immune Response Regulation Of Lamellipodium Assembly Protein Domain Specific Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Membrane Invagination Regulation Of Cell Communication Small GTPase-mediated Signal Transduction Regulation Of Signaling Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Non-canonical Wnt Signaling Pathway Cellular Response To Glucose Starvation Angiotensin Type I Receptor Activity Neural Nucleus Development Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Synapse Organization Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of TORC1 Signaling TORC1 Signaling DGTPase Activity DGTP Binding Triphosphoric Monoester Hydrolase Activity Deoxynucleoside Triphosphate Hydrolase Activity Regulation Of Defense Response G Protein Activity Regulation Of Immune System Process GTP Binding Cell Migration Bradykinin Receptor Binding Intracellular Protein Localization Cytoplasmic Ribonucleoprotein Granule
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