SAMHD1 and FBXO7

Number of citations of the paper that reports this interaction (PubMedID 27503909)
69

Data Source:
BioGRID (enzymatic study)

		SAMHD1	FBXO7
Description		SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	F-box protein 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Neurite Lewy Body Core Lewy Body Corona
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Catalytic Activity RNA Nuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Hydrolase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding Metal Ion Binding Deoxynucleoside Triphosphate Hydrolase Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Protein Heterodimerization Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Immune System Process DGTP Catabolic Process DNA Replication DNA Repair Immune Response DNA Damage Response Deoxyribonucleotide Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Innate Immune Response Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway DNA Strand Resection Involved In Replication Fork Processing	Autophagy Of Mitochondrion Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Mitochondrion Regulation Of Neuron Projection Development Protein Ubiquitination Lymphocyte Differentiation Regulation Of Protein Stability Regulation Of Locomotion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Lymphocyte Differentiation Protein K48-linked Ubiquitination Positive Regulation Of Mitophagy Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Nucleotide catabolism Interferon alpha/beta signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Aicardi-Goutieres Syndrome (AGS)	Parkinson's disease (PD)
GWAS		Caffeine consumption from coffee or tea ( 33287642) Height ( 28552196)	Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278)
Interacting Genes		15 interacting genes: ACTB APP ARAP3 CDK1 CHUK DYSF FAM13B FBXO25 FBXO7 IKBKB NONO SUMO2 TIRAP TRIM21 USP7	348 interacting genes: AATF ABCF3 ABL1 ACOT8 ACSL5 ACSM3 ACTC1 ACVR1 ACVR2B AK8 AKAP14 AKAP19 AKIRIN2 AKT3 ALKBH3 AMOTL2 ANGPTL7 ANKRD36BP1 ANP32E APEX1 APOBEC3C APOBEC4 ASPH ASPHD1 ATAT1 ATF5 ATP5F1C BAG3 BCKDK BIRC2 BLK BUB1 BUB1B C11orf16 C1orf105 C1orf115 C22orf31 CACYBP CAMK1 CAPN5 CASQ2 CCBE1 CCDC186 CCDC60 CCDC88C CCNE2 CDC34 CDK10 CDK14 CEP112 CFAP300 CHCHD2 CHCHD6 CHMP2B CHMP3 CILK1 CIRBP CKAP2 CLHC1 CLIP3 CMTR2 CNOT7 COLEC12 COXFA4L3 CPAP CPEB4 CRMA CSNK1E CXCL12 CXCL9 DDRGK1 DDX10 DHRS2 DHX40 DNAH14 DNAJA3 DNAJB12 DNAJC30 DPY19L2P1 DRAP1 ELF4 EP400P1 EPHA3 EPHB2 EPHB3 EPHB4 ERBB2 ERICH2 EYA2 FGF10 FGF13 FGFR1 FGFR2 FMOD FUT8 FYTTD1 GADD45GIP1 GAPDH GBP2 GEMIN2 GET4 GGA2 GLCE GLIPR2 GLRX2 GMCL2 GNLY GORAB GPAM GPKOW GRK6 GSK3B H1-0 H2AZ2 H3-3B HADH HMG20A HMG20B HMGB2 HMGCS2 HNRNPK HPF1 IDH2 IFT88 IGKV1-5 IL4 IL7 ILKAP INKA2 INPP5K INTS7 IPO9 IRF3 JADE2 KCNAB1 KCTD14 KHDRBS3 KIAA1586 KIF12 KIFC3 KIRREL3-AS3 KLF4 KMO KPNA5 LETMD1 LGALS3BP LIMK1 LIMK2 LINC01483 LMNA LRRC20 LRRC8E LRRFIP1 MAK MAP2K6 MAPK10 MAPK9 MAPRE2 MARK2 MARK3 MBD5 MBNL1 MCM2 MCM5 MDK MED22 MED27 MEF2D MEST MIS18BP1 MITF MMP13 MMP8 MNDA MOB3A MOB3C MPG MPP3 MPZL1 MRM3 MRPL27 MRPS14 MTIF3 MTUS1 MYOG NANS NDE1 NFIA NFIC NFKB1 NKD2 NPHP1 NUDT16L1 NUMB NVL ODF2L OLFML2A OR14K1 ORC3 OSTF1 PABPC3 PACRG PAFAH1B1 PAK6 PCBD2 PDCD7 PDE12 PDE4D PDGFB PGAP4 PHLDA1 PIEZO1 PIGY PIM1 PIM2 PINK1 PLEKHA1 PNOC PNRC2 POLDIP2 POLR2K PPHLN1 PPP1CB PPP1R17 PPP1R21 PRAME PRICKLE2 PRKACB PRKCA PRKCB PRKCG PRKN PRMT1 PRRC2B PUF60 PUSL1 QKI RBBP6 RBFOX2 RBM23 RBM33 RCC1 REEP3 REEP4 RET RGS1 RGS22 RNF121 RORB RPL14 RPL26 RPL36A RPL37A RPL3L RPL6 RPS15A RPS18 RPS19BP1 RPS2 RPS6KA3 RPS6KB1 RSL24D1 RWDD4 S100A13 S100A16 S100B SAMHD1 SCARA5 SDCCAG8 SEC16B SEC24C SET SFR1 SHANK3 SHMT1 SKP1 SLAIN1 SLC25A26 SLC35B3 SLC7A6OS SMARCD1 SMOC2 SNAP25 SNRPA SNX33 SPATA4 SPDYA SPRY2 SRCIN1 SRPK3 SRSF10 SRSF7 SS18L2 STAT6 STYX TAF9B TARDBP TBC1D3P2 TBPL1 TC2N TCP10L3 TEAD4 TEC TECR TECRL TENT5D TEX29 TGIF2 THAP7 TLE3 TMED10 TMEM120A TMEM237 TMOD2 TMPRSS5 TOMM20 TRAPPC12 TRIB3 TRIM44 TSBP1 TSLP TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2M UROD USF1 USH1C UXS1 VPS16 VRK3 WDR18 WDR24 XPO1 XRN1 YPEL5 ZBTB44 ZC2HC1C ZFYVE21 ZKSCAN8 ZMYM5 ZNF462 ZNF574 ZNF684 ZNF688
Entrez ID		25939	25793
HPRD ID		08418	07292
Ensembl ID		ENSG00000101347	ENSG00000100225
Uniprot IDs		A0A2R8YCS7 Q59H15 Q9Y3Z3	Q9Y3I1
PDB IDs		2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM 7A5Y 7LTT 7LU5 7S2Y 7UJN 8D94 8D9J 8GB1 8GB2 8QXJ 8QXK 8QXL 8QXM 8QXN 8QXO 8TDV 8TDW 9EC2	4L9C 4L9H
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response IkappaB Kinase Activity Post-translational Protein Modification Regulation Of Cellular Component Organization Innate Immune Response CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Transferrin Receptor Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Activation Of Innate Immune Response IkappaB Kinase Complex Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Positive Regulation Of Defense Response Defense Response To Other Organism Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Catabolic Process Regulation Of Circadian Rhythm Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Immune Response Immune System Process Regulation Of Type I Interferon Production Protein Ubiquitination Protein Heterodimerization Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Immune System Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Response To Copper Ion Regulation Of Proteolysis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex Immune Response	Protein Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Protein Phosphorylation Nucleoplasm Nucleus Protein Serine Kinase Activity Transferase Activity Phosphorylation Macromolecule Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Nucleotide Binding Nuclear Membrane Organization Negative Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Microtubule-based Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process F-box Domain Binding Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Primary Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cytoplasm Regulation Of Organelle Assembly Regulation Of Metabolic Process Nucleolus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Conjugating Enzyme Activity Structural Constituent Of Ribosome Nucleic Acid Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process RNA Binding B Cell Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Localization Regulation Of Protein Modification Process
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