SP3 and GRIN1

Number of citations of the paper that reports this interaction (PMID 14970236)
12

Data Source:
HPRD (in vivo)

		SP3	GRIN1
Gene Name		Sp3 transcription factor	glutamate receptor, ionotropic, N-methyl D-aspartate 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane PML Body Transcriptional Repressor Complex	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Dendrite Membrane Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Protein Binding Metal Ion Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Glycine Binding Glutamate Binding Enzyme Binding Voltage-gated Cation Channel Activity Glutamate Receptor Binding Neurotransmitter Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ossification Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter B Cell Differentiation T Cell Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis	Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Cellular Calcium Ion Homeostasis Synaptic Transmission Axon Guidance Respiratory Gaseous Exchange Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Propylene Metabolic Process Sensory Perception Of Pain Pons Maturation Cerebral Cortex Development Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription From RNA Polymerase II Promoter Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Rhythmic Process Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Tetramerization Response To Calcium Ion Regulation Of Synapse Assembly Calcium Ion Homeostasis Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition Male Mating Behavior Response To Fungicide Calcium Ion Transmembrane Transport Cellular Response To Manganese Ion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways			EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Orphenadrine Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran Agmatine
Diseases
GWAS			Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		19 interactors: E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF NKX3-1 PIAS1 RB1 RBBP4 SP1 STK19 SUMO1 TP53 UBE2I ZBTB7A	53 interactors: ACTN2 AKAP9 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B
Entrez ID		6670	2902
HPRD ID		03483	15926
Ensembl ID		ENSG00000172845	ENSG00000176884
Uniprot IDs		B7ZLN9 Q02447 Q59FX5 Q86TP0	Q05586 Q59GW0 Q5VSF9
PDB IDs			2HQW 2NR1 3BYA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Rhythmic Process RNA Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Chromatin Organization Regulation Of Signaling Response To Organic Substance Biosynthetic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signal Transduction Chromatin Modification Regulation Of Cell Cycle Chromatin Remodeling Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Substance Chromosome Organization Regulation Of Cell Proliferation Mitotic Cell Cycle Cellular Response To Hypoxia	Synaptic Transmission Cell-cell Signaling Nervous System Development Signaling Locomotion Cell Communication Neurogenesis Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Generation Of Neurons Neuron Projection Development Neuron Development Developmental Process Cell Development Neuron Differentiation Response To External Stimulus Signal Transduction Cell Projection Organization Movement Of Cell Or Subcellular Component Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development System Development Cellular Response To Stimulus Anatomical Structure Development Axon Development Axon Guidance Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Cellular Response To Organic Substance Response To Wounding Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Learning Response To Stimulus Regulation Of Signaling Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Abiotic Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cell Projection Morphogenesis Single-organism Behavior Cellular Response To Growth Factor Stimulus Learning Or Memory
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