SP3 and HLTF

Number of citations of the paper that reports this interaction (PubMedID 10391891)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SP3	HLTF
Description		Sp3 transcription factor	helicase like transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol PML Body Transcription Repressor Complex Protein-DNA Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Membrane Nuclear Matrix Nuclear Replication Fork RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding Catalytic Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding DNA Translocase Activity Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification In Utero Embryonic Development Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Myeloid Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis	Protein Polyubiquitination DNA Repair Chromatin Organization DNA Damage Response Protein Ubiquitination MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Replication Fork Reversal
Pathways		SUMOylation of transcription factors	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745 29874175) Sensation seeking ( 30718321)
Interacting Genes		30 interacting genes: AKT1 CIB3 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF LIN54 MAP1LC3A NKX3-1 PHF21A PIAS1 POGZ RB1 RBBP4 RPS20 SNRPB SP1 SPANXN2 SUMO1 TP53 TP73 UBE2I VEGFA WHR1 ZBTB7A	14 interacting genes: CDK9 CEBPA DCAF1 EEF1G EWSR1 HSPA8 SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4
Entrez ID		6670	6596
HPRD ID		03483	04461
Ensembl ID		ENSG00000172845	ENSG00000071794
Uniprot IDs		B7ZLN9 Q02447 Q59FX5 Q86TP0	A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527
PDB IDs			2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F 6KCS
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stress DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Chromatin Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Gene Expression Transcription Coregulator Binding DNA Binding Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Enzyme Binding Regulation Of Gliogenesis Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Regulation Of Nervous System Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Development Response To Oxygen Levels Histone Deacetylase Binding Nucleus Chromatin Organization Response To Stress Regulation Of Neurogenesis Cellular Response To Decreased Oxygen Levels DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Process	Nucleoplasm Nucleus Host-mediated Perturbation Of Viral Transcription Host-mediated Activation Of Viral Transcription Granulocyte Differentiation Embryonic Placenta Development Protein Ubiquitination Protein Modification By Small Protein Conjugation Host-mediated Activation Of Viral Process Post-translational Protein Modification Postreplication Repair Ubiquitin Conjugating Enzyme Activity Nucleic Acid Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Protein-DNA Complex Cellular Response To Wortmannin Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Cellular Response To Stress Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Transcription Cis-regulatory Region Binding Transcription Repressor Complex P-TEFb Complex Response To Vitamin B2 C/EBP Complex Lumenal Side Of Lysosomal Membrane Response To Wortmannin Cholesterol Sulfotransferase Activity Error-free Postreplication DNA Repair Host-mediated Perturbation Of Viral Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mononuclear Cell Differentiation DNA Metabolic Process Positive Regulation Of Protein Localization To Chromatin CHOP-C/EBP Complex Regulation Of Protein Import UBC13-MMS2 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process ATP Binding Regulation Of Nucleobase-containing Compound Metabolic Process
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