SP3 and WHR1

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
HPRD (two hybrid)

		SP3	WHR1
Description		Sp3 transcription factor	winged helix repair factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol PML Body Transcription Repressor Complex Protein-DNA Complex	Nucleus Cytoplasm Nuclear Speck
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Double-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Serine/threonine Kinase Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification In Utero Embryonic Development Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Myeloid Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis	DNA Repair DNA Damage Response Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Single Strand Break Repair
Pathways		SUMOylation of transcription factors
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745 29874175) Sensation seeking ( 30718321)
Interacting Genes		30 interacting genes: AKT1 CIB3 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF LIN54 MAP1LC3A NKX3-1 PHF21A PIAS1 POGZ RB1 RBBP4 RPS20 SNRPB SP1 SPANXN2 SUMO1 TP53 TP73 UBE2I VEGFA WHR1 ZBTB7A	13 interacting genes: BHLHE40 MAB21L3 PFDN5 PICK1 POLE POLR2G PRAME SF3B4 SLC29A1 SP3 TBRG4 TRIM23 VIM
Entrez ID		6670	8859
HPRD ID		03483	07281
Ensembl ID		ENSG00000172845	ENSG00000204344
Uniprot IDs		B7ZLN9 Q02447 Q59FX5 Q86TP0	A0A1U9X8L3 P49842
PDB IDs			7XRB 8YCM 9BZ0 9ER2 9FD2
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stress DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Chromatin Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Gene Expression Transcription Coregulator Binding DNA Binding Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Enzyme Binding Regulation Of Gliogenesis Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Regulation Of Nervous System Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Development Response To Oxygen Levels Histone Deacetylase Binding Nucleus Chromatin Organization Response To Stress Regulation Of Neurogenesis Cellular Response To Decreased Oxygen Levels DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Process
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