DST and TNIK

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		DST	TNIK
Gene Name		dystonin	TRAF2 and NCK interacting kinase
Image
Gene Ontology Annotations	Cellular Component	Basement Membrane Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Cytosol Intermediate Filament Focal Adhesion Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Z Disc Hemidesmosome Axon Cell Leading Edge H Zone Microtubule Plus-end Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Microtubule Plus-end Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cell Cycle Arrest Cell Adhesion Integrin-mediated Signaling Pathway Response To Wounding Maintenance Of Cell Polarity Extracellular Matrix Organization Hemidesmosome Assembly Intermediate Filament Cytoskeleton Organization Cell Motility	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		Cell junction organization Type I hemidesmosome assembly	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Brain imaging in schizophrenia (interaction) ( 19023125) Coronary heart disease ( 21347282)
Protein-Protein Interactions		26 interactors: APC CALM1 CDC5L CELSR3 CEP63 COL17A1 DCTN1 DISC1 DTNBP1 ERBB2IP EXOC1 ITGB4 ITSN2 KIAA0368 KIAA1549 KRT14 KRT5 MAPK6 NFYC PAK2 PRKAB2 PRKD2 SH3BP5 SMAD9 TNIK TRAF3IP1	38 interactors: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DISC1 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SLC9A1 SMARCE1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		667	23043
HPRD ID		00222	18206
Ensembl ID		ENSG00000151914	ENSG00000154310
Uniprot IDs		B4DGY0 B4DSS9 Q03001 Q6P0N6	Q9UKE5
PDB IDs		3GJO	2X7F
Enriched GO Terms of Interacting Partners?		Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Junction Assembly Signaling Organelle Organization Cell Communication Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Kinase Activity Anatomical Structure Development Regulation Of Phosphorylation Cell Cycle Nervous System Development Developmental Process Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Epithelium Development Regulation Of Cellular Protein Metabolic Process Microtubule-based Process Cytoskeleton Organization Response To Stimulus Cell Projection Organization Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Epidermis Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Projection Assembly Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport System Development Regulation Of Catalytic Activity Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell Adhesion Regulation Of Signal Transduction	Neurogenesis Nervous System Development Cellular Component Assembly Movement Of Cell Or Subcellular Component Cell Differentiation Organelle Organization Generation Of Neurons Cytoskeleton Organization Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Locomotion Regulation Of Cell Projection Organization System Development Regulation Of Neuron Differentiation Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Size Signaling Multicellular Organismal Development Signal Transduction Cell Projection Organization Cell Communication Regulation Of Neurogenesis Cellular Localization Plasma Membrane Organization Regulation Of Signal Transduction Axonogenesis Developmental Process Positive Regulation Of Signal Transduction Axon Guidance Axon Development Cellular Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Cell Morphogenesis Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Regulation Of Cell Development Regulation Of Signaling Cell Part Morphogenesis Neuron Projection Morphogenesis Neuron Differentiation Golgi To Plasma Membrane Protein Transport Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Cell Polarity Cell Development Protein Localization To Organelle Cell Morphogenesis Involved In Differentiation
Tagcloud ?		125i alanine amines analogous asked attach attached attaches attempted b2 bradykinin bromide covalently cyanogen disuccinimidyl epsilon exchanged homobifunctional immunoidentification k174a labeling linker lys172 lys174 reacts reagent tartarate tyr8 worked	a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Difference) ?		125i alanine amines analogous asked attach attached attaches attempted b2 bradykinin bromide covalently cyanogen disuccinimidyl epsilon exchanged homobifunctional immunoidentification k174a labeling linker lys172 lys174 reacts reagent tartarate tyr8 worked	a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Intersection) ?