DST and MYBPC2

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		DST	MYBPC2
Name		dystonin	myosin binding protein C2
Structure
GO Annotations	Cellular Component	Stress Fiber Basement Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Focal Adhesion Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Z Disc Hemidesmosome Axon Cell Leading Edge Cytoplasmic Vesicle H Zone Microtubule Plus-end Cell Projection Intermediate Filament Cytoskeleton Anchoring Junction Cell Periphery Polymeric Cytoskeletal Fiber Axon Cytoplasm	Cytosol M Band Myosin Filament
	Molecular Function	Actin Binding Integrin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Metal Ion Binding Microtubule Plus-end Binding	Actin Binding Protein Binding Structural Constituent Of Muscle
	Biological Process	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Retrograde Axonal Transport Response To Wounding Maintenance Of Cell Polarity Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization Cell Motility	Cell Adhesion Sarcomere Organization
Pathways		Type I hemidesmosome assembly RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Striated Muscle Contraction
GWAS		Alzheimer disease and age of onset ( 26830138 ) Appendicular lean mass ( 33097823 ) Attention function in attention deficit hyperactive disorder ( 26174813 ) Cerebrospinal fluid clusterin levels ( 26545630 ) Daytime sleep phenotypes ( 27126917 ) Gout (normal type) ( 32238385 ) Heel bone mineral density ( 30598549 ) Mean spheric corpuscular volume ( 32888494 ) Menarche (age at onset) ( 25231870 ) Red blood cell count ( 32888494 ) Small cell lung carcinoma ( 28604730 )	Primary biliary cholangitis ( 26394269 )
Interacting Genes		50 interacting genes: ABI1 ANKRD1 APC C1QTNF9 CALM1 CDC5L CELSR3 CEP63 CLIP4 COL17A1 DCTN1 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EIF4ENIF1 ERBB2 ERBIN EXOC1 FTCD HUNK ITGB4 ITSN1 ITSN2 KIAA1549 KRT14 KRT5 LINC01554 MAPK6 MORC3 MTNR1B MYBPC2 NFYC NRIP1 PAK2 PCNT PRKAB2 PRKD2 PTGER4 RBM11 RSPH1 SH3BP5 SMAD9 SNAPIN TNIK TRAF3IP1 TTC3 TULP3 USP7	31 interacting genes: ACTN2 AMOT AOC3 CCT6A CMYA5 COL12A1 DST DYSF FLNB FLNC FSD2 GABARAP GAS7 HSPA1B ITGB5 MAD2L2 MSN MYBPC1 MYBPH MYH8 MYOM2 NF2 PCDH12 PDE4DIP RANBP2 SDCBP SGCG TRIM63 TRIP11 TTN TULP3
Entrez ID		667	4606
HPRD ID		00222	01184
Ensembl ID		ENSG00000151914	ENSG00000086967
Uniprot IDs		A0A7P0T890 B4DGY0 B4DSS9 E9PHM6 F6QMI7 F8W9J4 Q03001 Q6P0N6	A0A140VJQ0 Q14324
PDB IDs		3GJO 7OLG	2E7C 2EDK 2EDN
GO Terms Enriched among Interactors		Signal Transduction Hemidesmosome Cytoskeleton Organization Intracellular Signal Transduction Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Dendritic Spine Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Centrosome Developmental Process Cytosol Hemidesmosome Assembly Cytoplasm Vesicle-mediated Transport In Synapse Organelle Organization Molecular Adaptor Activity Anatomical Structure Morphogenesis Cytoskeleton Regulation Of Neuron Projection Development Ciliary Base Presynaptic Endocytosis Cellular Component Assembly Cell Junction Organization Dendrite Morphogenesis Cell Surface Receptor Signaling Pathway Protein Binding Microtubule-based Process Protein Phosphorylation Plasma Membrane Bounded Cell Projection Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Titin Binding Nucleoplasm Cell Junction Assembly Regulation Of Cell Projection Organization Cell Projection Assembly Cell Leading Edge Cilium Assembly Axonal Transport Organelle Assembly Neuron Cellular Homeostasis Dendritic Spine Development Neuron Projection Morphogenesis Phosphorylation Basal Plasma Membrane Protein Tyrosine Kinase Activator Activity Embryonic Camera-type Eye Development Negative Regulation Of Interferon-beta Production Anterograde Synaptic Vesicle Transport BLOC-1 Complex Positive Regulation Of Cell Growth	Actin Filament-based Process M Band Actin Cytoskeleton Organization Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Actomyosin Structure Organization Myosin Filament Z Disc Cytoskeletal Protein Binding Organelle Organization Actin Binding Cytoskeleton Focal Adhesion Titin Binding Positive Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Cell Adhesion Positive Regulation Of Cytoskeleton Organization Actin Filament Binding Myofibril Positive Regulation Of Microtubule Nucleation Positive Regulation Of Early Endosome To Late Endosome Transport Actin Cytoskeleton Integrin Binding Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cellular Component Biogenesis Muscle Filament Sliding Phosphatidylinositol-4,5-bisphosphate Binding Filopodium Pseudopodium Actin-myosin Filament Sliding Regulation Of Early Endosome To Late Endosome Transport Muscle Contraction Stress Fiber Regulation Of Microtubule Nucleation Regulation Of Supramolecular Fiber Organization Extracellular Exosome Calcium Ion Binding Positive Regulation Of Cellular Component Organization Plasma Membrane Enzyme Binding Muscle Cell Development Sarcolemma Muscle System Process Regulation Of Organelle Assembly Regulation Of Intracellular Transport