SCN4A and DLG3

Number of citations of the paper that reports this interaction (PubMedID 16637659)
54

Data Source:
HPRD (in vitro)

		SCN4A	DLG3
Description		sodium voltage-gated channel alpha subunit 4	discs large MAGUK scaffold protein 3
Image
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Monoatomic Ion Channel Complex	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Action Potential Monoatomic Ion Transport Sodium Ion Transport Muscle Contraction Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Skeletal Muscle Contraction By Action Potential	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Ranolazine Topiramate Lidocaine Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Chloroprocaine Flecainide Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Parachlorophenol Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		Congenital myasthenic syndrome Hyperkalemic periodic paralysis (HyperPP) Hypokalemic periodic paralysis (HypoPP) Paramyotonia congenita (PMC) Potassium-aggravated myotonias (PAMs), including: Myotonia fluctuans; Myotonia permanens; Acetazolamide responsive myotonia	Non-syndromic X-linked mental retardation
GWAS		Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 34021172)	Mean platelet volume ( 32888494)
Interacting Genes		10 interacting genes: CALM1 DLG1 DLG2 DLG3 ERBIN NHERF1 PATJ SNTA1 SNTB1 SNTB2	51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN
Entrez ID		6329	1741
HPRD ID		04912	02177
Ensembl ID		ENSG00000007314	ENSG00000082458
Uniprot IDs		P35499	Q59FY1 Q92796
PDB IDs		6AGF 6MBA 6MC9	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Neuromuscular Junction Anchoring Junction Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Dystrophin-associated Glycoprotein Complex Ionotropic Glutamate Receptor Binding Plasma Membrane Receptor Localization To Synapse Receptor Clustering Phosphatase Binding Protein Localization To Synapse Basolateral Plasma Membrane Regulation Of Sodium Ion Transport GMP Kinase Activity PDZ Domain Binding Protein Localization To Cell Junction GDP Metabolic Process Protein Localization To Membrane Kinase Binding Postsynaptic Density Membrane Regulation Of Metal Ion Transport Sarcolemma Bicellular Tight Junction Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Protein Kinase Binding Regulation Of Cardiac Muscle Cell Action Potential GMP Metabolic Process Structural Molecule Activity Regulation Of Biological Quality Adherens Junction Localization Within Membrane Calmodulin Binding Regulation Of Heart Contraction Cell Junction Muscle Contraction Regulation Of System Process Regulation Of Sodium Ion Transmembrane Transport Regulation Of Blood Circulation Sperm Midpiece Muscle System Process Regulation Of Monoatomic Cation Transmembrane Transport Tight Junction Assembly Tight Junction Organization Regulation Of Action Potential	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane
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