SCN4A and SLC9A3R1

Number of citations of the paper that reports this interaction (PMID 9677412)
88

Data Source:
BioGRID (unspecified method)

		SCN4A	SLC9A3R1
Gene Name		sodium channel, voltage gated, type IV alpha subunit	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece
	Molecular Function	Voltage-gated Sodium Channel Activity	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding
	Biological Process	Sodium Ion Transport Muscle Contraction Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS			Fibrinogen ( 20031577)
Protein-Protein Interactions		10 interactors: CALM1 DLG1 DLG2 DLG3 ERBB2IP INADL SLC9A3R1 SNTA1 SNTB1 SNTB2	52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468
Entrez ID		6329	9368
HPRD ID		04912	05406
Ensembl ID		ENSG00000007314	ENSG00000109062
Uniprot IDs		P35499	O14745
PDB IDs			1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Sodium Ion Transmembrane Transport Muscle Contraction Receptor Clustering Nucleotide Phosphorylation Muscle System Process Regulation Of Sodium Ion Transport Regulation Of Phosphatase Activity Regulation Of Ion Transmembrane Transport Regulation Of Dephosphorylation Establishment Or Maintenance Of Cell Polarity Synaptic Transmission Regulation Of Ion Transport Cellular Protein Localization Cellular Localization Negative Regulation Of Protein Kinase B Signaling Regulation Of Phosphorus Metabolic Process Negative Regulation Of Transporter Activity Negative Regulation Of Ion Transmembrane Transport Tight Junction Assembly Membrane Organization Negative Regulation Of Transmembrane Transport Negative Regulation Of Phosphatase Activity Cell-cell Signaling Protein Localization To Membrane Negative Regulation Of Dephosphorylation Protein Localization Apical Junction Assembly Regulation Of Heart Rate Organophosphate Metabolic Process Regulation Of Cardiac Muscle Contraction Regulation Of Vasoconstriction By Circulating Norepinephrine Renal Phosphate Ion Absorption Regulation Of Striated Muscle Contraction Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Ion Transport Negative Regulation Of Sodium:proton Antiporter Activity Basal Protein Localization Glutathione Transport Cell-cell Junction Assembly Regulation Of Catalytic Activity Regulation Of Protein Kinase B Signaling Signaling Nucleotide Metabolic Process Cell Communication Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity	Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process
Tagcloud ?		blotting chorionic cloned cs deoxyribonuclease evolutionarily genomes gh homologue hypersensitive immediately implies insert kb kilobases linkage loci locus orientation p1 physically pig pituitary somatomammotropin sug transcriptase trip ubiquitously unlike	adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Difference) ?		blotting chorionic cloned cs deoxyribonuclease evolutionarily genomes gh homologue hypersensitive immediately implies insert kb kilobases linkage loci locus orientation p1 physically pig pituitary somatomammotropin sug transcriptase trip ubiquitously unlike	adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Intersection) ?