FSCN1 and ACTC1

Number of citations of the paper that reports this interaction (PMID 12139639)
13

Data Source:
HPRD (in vivo)

		FSCN1	ACTC1
Gene Name		fascin actin-bundling protein 1	actin, alpha, cardiac muscle 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Actin Cytoskeleton Cell Junction Filopodium Extracellular Vesicular Exosome Invadopodium	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding Protein Binding Drug Binding Protein Binding, Bridging Poly(A) RNA Binding Actin Filament Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Cell Proliferation Cell Migration Actin Cytoskeleton Organization Cell Motility Actin Filament Bundle Assembly	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		10 interactors: ACTA1 ACTC1 CTNNB1 DNAJB9 MAPK8IP2 NGFR PRKCA PRKCD RAB1A YWHAQ	35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1
Entrez ID		6624	70
HPRD ID		04068	00015
Ensembl ID		ENSG00000075618	ENSG00000159251
Uniprot IDs		B3KTA3 J3KNT0 Q16658	B3KPP5 P68032
PDB IDs		1DFC 3LLP 3O8K 3P53 4GOV 4GOY 4GP0 4GP3
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Skeletal Muscle Thin Filament Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Insulin Stimulus Skeletal Myofibril Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Glial Cell Apoptotic Process Apoptotic Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Regulation Of Cell Death Response To Organic Substance Developmental Process Regulation Of Platelet Aggregation Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Cell Death Response To Stimulus Cell Development Response To External Stimulus Cellular Component Assembly Positive Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Platelet Activation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Hair Follicle Morphogenesis Response To Growth Factor Cellular Response To Stimulus Actin-myosin Filament Sliding Muscle Filament Sliding Neurotrophin TRK Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cell Death Neurotrophin Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Anatomical Structure Development Cell Differentiation Defense Response Negative Regulation Of Insulin Receptor Signaling Pathway	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly
Tagcloud ?		133b accurately adjacent backgroundincreasing bundling conclusionour contrary detailed evidences exerted fascin functioned gc ges introduced invasion knockdown methodswe micrornas mimics mir modulating neoplastic oncogenes pairs resultsmir suppressors taqman venous	accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Difference) ?		133b accurately adjacent backgroundincreasing bundling conclusionour contrary detailed evidences exerted fascin functioned gc ges introduced invasion knockdown methodswe micrornas mimics mir modulating neoplastic oncogenes pairs resultsmir suppressors taqman venous	accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Intersection) ?