FSCN1 and NGFR

Number of citations of the paper that reports this interaction (PMID 12789270)
11

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FSCN1	NGFR
Gene Name		fascin actin-bundling protein 1	nerve growth factor receptor
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Actin Cytoskeleton Cell Junction Filopodium Extracellular Vesicular Exosome Invadopodium	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density
	Molecular Function	Actin Binding Protein Binding Drug Binding Protein Binding, Bridging Poly(A) RNA Binding Actin Filament Binding	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding
	Biological Process	Cell Proliferation Cell Migration Actin Cytoskeleton Organization Cell Motility Actin Filament Bundle Assembly	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways			Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)
Protein-Protein Interactions		10 interactors: ACTA1 ACTC1 CTNNB1 DNAJB9 MAPK8IP2 NGFR PRKCA PRKCD RAB1A YWHAQ	45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274
Entrez ID		6624	4804
HPRD ID		04068	01197
Ensembl ID		ENSG00000075618	ENSG00000064300
Uniprot IDs		B3KTA3 J3KNT0 Q16658	P08138
PDB IDs		1DFC 3LLP 3O8K 3P53 4GOV 4GOY 4GP0 4GP3	3EWV
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Skeletal Muscle Thin Filament Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Insulin Stimulus Skeletal Myofibril Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Glial Cell Apoptotic Process Apoptotic Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Regulation Of Cell Death Response To Organic Substance Developmental Process Regulation Of Platelet Aggregation Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Cell Death Response To Stimulus Cell Development Response To External Stimulus Cellular Component Assembly Positive Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Platelet Activation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Hair Follicle Morphogenesis Response To Growth Factor Cellular Response To Stimulus Actin-myosin Filament Sliding Muscle Filament Sliding Neurotrophin TRK Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cell Death Neurotrophin Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Anatomical Structure Development Cell Differentiation Defense Response Negative Regulation Of Insulin Receptor Signaling Pathway	Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Tagcloud ?		133b accurately adjacent backgroundincreasing bundling conclusionour contrary detailed evidences exerted fascin functioned gc ges introduced invasion knockdown methodswe micrornas mimics mir modulating neoplastic oncogenes pairs resultsmir suppressors taqman venous	acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Difference) ?		133b accurately adjacent backgroundincreasing bundling conclusionour contrary detailed evidences exerted fascin functioned gc ges introduced invasion knockdown methodswe micrornas mimics mir modulating neoplastic oncogenes pairs resultsmir suppressors taqman venous	acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Intersection) ?