SMO and GABBR1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SMO	GABBR1
Description		smoothened, frizzled class receptor	gamma-aminobutyric acid type B receptor subunit 1
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GO Annotations	Cellular Component	Cytoplasm Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Plasma Membrane Caveola Cilium Membrane Dendrite Endocytic Vesicle Membrane Cell Projection Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium Plasma Membrane Bounded Cell Projection	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Membrane Dendrite Axolemma Mitochondrial Membrane G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Heterodimeric Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Synapse Postsynaptic Membrane Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse GABA Receptor Complex G Protein-coupled GABA Receptor Complex
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Patched Binding Protein Binding Oxysterol Binding Protein Kinase A Catalytic Subunit Binding Protein Sequestering Activity	G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Extracellular Matrix Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Negative Regulation Of Protein Phosphorylation Hair Follicle Development Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Heart Morphogenesis Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development Protein Import Into Nucleus Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Determination Of Left/right Symmetry Ventral Midline Determination Pattern Specification Process Neuroblast Proliferation Central Nervous System Development Midgut Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Tissue Development Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Spinal Cord Dorsal/ventral Patterning Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Cell Development Digestive Tract Development Embryonic Organ Development Developmental Growth Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Response To Inositol Regulation Of Somatic Stem Cell Population Maintenance Regulation Of Heart Morphogenesis	Osteoblast Differentiation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Glutamate Secretion Positive Regulation Of Glutamate Secretion Negative Regulation Of Gamma-aminobutyric Acid Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Dopamine Secretion Response To Nicotine Response To Ethanol Negative Regulation Of Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Regulation Of Presynaptic Membrane Potential Neuron-glial Cell Signaling
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO	Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib	Baclofen Acamprosate Progabide Taurine gamma-Aminobutyric acid SGS-742 Tezampanel Arbaclofen Arbaclofen Placarbil Sodium oxybate L-Baclofen
Diseases		Basal cell carcinoma
GWAS		Osteoarthritis (hip) ( 30374069)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Depression ( 33859377) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nasopharyngeal carcinoma ( 19664746) Nicotine dependence ( 28440896) Platelet count ( 26805783) Schizophrenia ( 27922604) Subcortical volume (MOSTest) ( 32665545) Ulna and radius bone mineral density ( 30172743) White blood cell count ( 27863252)
Interacting Genes		28 interacting genes: ARLN ARV1 C18orf32 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS	16 interacting genes: ATF5 BDKRB1 CCR8 CHFR CPEB2 DRD2 GABBR2 GNAO1 GPR37 JAKMIP1 KCNJ6 MAX NSF RGS4 SMO YWHAZ
Entrez ID		6608	2550
HPRD ID		03294	04644
Ensembl ID		ENSG00000128602	ENSG00000204681
Uniprot IDs		Q99835	A0A0G2JKF9 A0A1U9X7R0 C9J342 Q59HG8 Q5SUJ9 Q8IW08 Q9UBS5
PDB IDs		4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM 7ZI0	4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6HKC 6UO8 6UO9 6UOA 6VJM 6W2X 6W2Y 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Heme Oxidation Heme Oxygenase (decyclizing) Activity Hedgehog Family Protein Binding Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Dorsal/ventral Neural Tube Patterning Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Cell Fate Specification Magnesium Ion Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dopamine Receptor Signaling Pathway Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neural Precursor Cell Proliferation GABA-ergic Synapse G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Transport Peptide Binding G-protein Alpha-subunit Binding Dopamine Metabolic Process Positive Regulation Of Neuroblast Proliferation Ionotropic Glutamate Receptor Binding Response To Amphetamine Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organism Growth Regulation Of Monoatomic Ion Transport Negative Regulation Of Blood Pressure Response To Amine Negative Regulation Of Insulin Secretion Regulation Of Neuroblast Proliferation Response To Cocaine Catecholamine Metabolic Process Regulation Of Heart Contraction Neuroblast Proliferation Negative Regulation Of Peptide Secretion Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Protein Sequestering Activity Ventral Midline Determination Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Protein Localization Regulation Of Biological Quality Ciliary Membrane Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Bradykinin Receptor Activity Regulation Of Blood Circulation Negative Regulation Of Hormone Secretion Biogenic Amine Metabolic Process Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Response To Alcohol Mu-type Opioid Receptor Binding Prosaposin Receptor Activity
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