SMO and PTCH1

Number of citations of the paper that reports this interaction (PMID 9811851)
27

Data Source:
HPRD (in vivo)

		SMO	PTCH1
Gene Name		smoothened, frizzled class receptor	patched 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Integral Component Of Membrane Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium Ciliary Tip	Golgi Apparatus Plasma Membrane Caveola Postsynaptic Density Integral Component Of Membrane Midbody Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Ciliary Membrane Primary Cilium
	Molecular Function	G-protein Coupled Receptor Activity Patched Binding Protein Binding Drug Binding Wnt-protein Binding Wnt-activated Receptor Activity	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein Complex Binding Hedgehog Family Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development G-protein Coupled Receptor Signaling Pathway Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Ventral Midline Determination Midgut Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Central Nervous System Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Skeletal Muscle Fiber Development Forebrain Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Canonical Wnt Signaling Pathway Detection Of Cell Density By Contact Stimulus Involved In Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Cellular Response To Cholesterol Renal System Development Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Maintenance Regulation Of Heart Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Smoothened Signaling Pathway Regulation Of Mitotic Cell Cycle Brain Development Epidermis Development Regulation Of Smoothened Signaling Pathway Response To Mechanical Stimulus Organ Morphogenesis Dorsal/ventral Pattern Formation Response To Chlorate Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinocyte Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Embryonic Organ Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Renal System Development Cell Proliferation Involved In Metanephros Development Protein Targeting To Plasma Membrane
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Hedgehog 'off' state Assembly of the primary cilium GPCR ligand binding Metabolic disorders of biological oxidation enzymes BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors) Activation of SMO	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Metabolic disorders of biological oxidation enzymes GPCR ligand binding Ligand-receptor interactions Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Height ( 18391952) Pulmonary function ( 20010835) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		3 interactors: NEDD4 PTCH1 PTCH2	7 interactors: CCNB1 CDK1 DHH HIPK2 IHH SHH SMO
Entrez ID		6608	5727
HPRD ID		03294	03200
Ensembl ID		ENSG00000128602	ENSG00000185920
Uniprot IDs		A4D1K5 Q99835	Q13635 Q59FG5
PDB IDs		4JKV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Signaling Neural Plate Axis Specification Response To Chlorate Heart Morphogenesis Epidermis Development Tissue Development Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Protein Targeting Glucocorticoid Receptor Signaling Pathway Cell Proliferation Involved In Metanephros Development Response To Inorganic Substance Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Heart Development Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Keratinocyte Proliferation Cell Proliferation Involved In Kidney Development Regulation Of Signal Transduction Cellular Response To Cholesterol Protein Localization To Lysosome Neural Plate Development Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Regulation Of Signaling Negative Regulation Of Multicellular Organism Growth Receptor Catabolic Process Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Pharyngeal System Development Response To Cholesterol Protein Targeting To Vacuole Positive Regulation Of Transport Regulation Of Cholesterol Efflux Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Vacuole Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cardiovascular System Development Protein K63-linked Ubiquitination Intracellular Protein Transport Dorsal/ventral Neural Tube Patterning	Muscle Tissue Development Positive Regulation Of Cell Proliferation Smoothened Signaling Pathway Digestive Tract Development Digestive System Development Intein-mediated Protein Splicing Heart Development Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Smoothened Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Organ Development Heart Looping Positive Regulation Of Hh Target Transcription Factor Activity Determination Of Heart Left/right Asymmetry Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Embryonic Heart Tube Morphogenesis Cell Fate Commitment Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Positive Regulation Of Stem Cell Proliferation Striated Muscle Tissue Development Tissue Development Muscle Cell Differentiation Embryonic Organ Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Cardiovascular System Development Cell Development Cell Differentiation Response To Organic Cyclic Compound Embryonic Heart Tube Development Cell-cell Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Negative Regulation Of Cell Death Epithelial-mesenchymal Cell Signaling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation
Tagcloud ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smoothened sonic u373mg u87mg verify warrants wox1 wtp53 ww wwox zerumbone	actinic basel brm constituents culminating damages destroying detrimental division drive enabling hras immunity immunosuppression incorrect interfere karger keratosis lipids mast mutagenesis photodamage photodamaged steps stops synthesised ultraviolet unrepaired uv
Tagcloud (Difference) ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smoothened sonic u373mg u87mg verify warrants wox1 wtp53 ww wwox zerumbone	actinic basel brm constituents culminating damages destroying detrimental division drive enabling hras immunity immunosuppression incorrect interfere karger keratosis lipids mast mutagenesis photodamage photodamaged steps stops synthesised ultraviolet unrepaired uv
Tagcloud (Intersection) ?