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SMO
Gene Name
smoothened, frizzled class receptor
Image
Gene Ontology Annotations
Cellular Component
Golgi Apparatus
Plasma Membrane
Caveola
Integral Component Of Membrane
Endocytic Vesicle Membrane
Intracellular Membrane-bounded Organelle
Ciliary Membrane
Extracellular Vesicular Exosome
Primary Cilium
Ciliary Tip
Molecular Function
G-protein Coupled Receptor Activity
Patched Binding
Protein Binding
Drug Binding
Wnt-protein Binding
Wnt-activated Receptor Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Vasculogenesis
Osteoblast Differentiation
In Utero Embryonic Development
Cell Fate Specification
Neural Crest Cell Migration
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Determination Of Left/right Asymmetry In Lateral Mesoderm
Type B Pancreatic Cell Development
G-protein Coupled Receptor Signaling Pathway
Smoothened Signaling Pathway
Positive Regulation Of Hh Target Transcription Factor Activity
Ventral Midline Determination
Midgut Development
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Cerebellar Cortex Morphogenesis
Thalamus Development
Dorsal/ventral Neural Tube Patterning
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Central Nervous System Neuron Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Hair Follicle Morphogenesis
Protein Localization To Nucleus
Multicellular Organism Growth
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Positive Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Developmental Growth
Skeletal Muscle Fiber Development
Forebrain Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Protein Stabilization
Myoblast Migration
Negative Regulation Of Hair Follicle Development
Canonical Wnt Signaling Pathway
Detection Of Cell Density By Contact Stimulus Involved In Contact Inhibition
Atrial Septum Morphogenesis
Mammary Gland Epithelial Cell Differentiation
Epithelial-mesenchymal Cell Signaling
Somite Development
Pancreas Morphogenesis
Cellular Response To Cholesterol
Renal System Development
Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Regulation Of Stem Cell Maintenance
Regulation Of Heart Morphogenesis
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
Cargo trafficking to the periciliary membrane
Organelle biogenesis and maintenance
Hedgehog 'off' state
Assembly of the primary cilium
GPCR ligand binding
Metabolic disorders of biological oxidation enzymes
BBSome-mediated cargo-targeting to cilium
Hedgehog 'on' state
Signaling by Hedgehog
Class B/2 (Secretin family receptors)
Activation of SMO
Drugs
Diseases
GWAS
Protein-protein Interactions
3 interactors:
NEDD4
PTCH1
PTCH2
Entrez ID
6608
HPRD ID
03294
Ensembl ID
ENSG00000128602
Uniprot IDs
A4D1K5
Q99835
PDB IDs
4JKV
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Smoothened Signaling Pathway
Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Signal Transduction
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Transmission Of Virus
Development Involved In Symbiotic Interaction
Negative Regulation Of Signaling
Neural Plate Axis Specification
Response To Chlorate
Heart Morphogenesis
Epidermis Development
Tissue Development
Progesterone Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Protein Targeting
Glucocorticoid Receptor Signaling Pathway
Cell Proliferation Involved In Metanephros Development
Response To Inorganic Substance
Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Heart Development
Protein Targeting To Lysosome
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Keratinocyte Proliferation
Cell Proliferation Involved In Kidney Development
Regulation Of Signal Transduction
Cellular Response To Cholesterol
Protein Localization To Lysosome
Neural Plate Development
Cellular Response To Sterol
Positive Regulation Of Cholesterol Efflux
Regulation Of Signaling
Negative Regulation Of Multicellular Organism Growth
Receptor Catabolic Process
Positive Regulation Of Cholesterol Transport
Mammary Gland Epithelial Cell Differentiation
Pharyngeal System Development
Response To Cholesterol
Protein Targeting To Vacuole
Positive Regulation Of Transport
Regulation Of Cholesterol Efflux
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Establishment Of Protein Localization To Vacuole
Regulation Of Potassium Ion Transmembrane Transporter Activity
Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cardiovascular System Development
Protein K63-linked Ubiquitination
Intracellular Protein Transport
Dorsal/ventral Neural Tube Patterning
Tagcloud
?
breaks
crosstalk
cyclopamine
ectopically
gbm
gli
glioblastoma
h2ax
hedgehog
impairing
ionizing
mtp53
multiforme
oxidoreductase
possessing
radiosensitivity
sensitize
shh
smoothened
sonic
u373mg
u87mg
verify
warrants
wox1
wtp53
ww
wwox
zerumbone