GABBR1 and GPR37

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GABBR1	GPR37
Description		gamma-aminobutyric acid type B receptor subunit 1	G protein-coupled receptor 37
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Membrane Dendrite Axolemma Mitochondrial Membrane G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Heterodimeric Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Synapse Postsynaptic Membrane Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse GABA Receptor Complex G Protein-coupled GABA Receptor Complex	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Extracellular Matrix Protein Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Osteoblast Differentiation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Glutamate Secretion Positive Regulation Of Glutamate Secretion Negative Regulation Of Gamma-aminobutyric Acid Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Dopamine Secretion Response To Nicotine Response To Ethanol Negative Regulation Of Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Regulation Of Presynaptic Membrane Potential Neuron-glial Cell Signaling	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Baclofen Acamprosate Progabide Taurine gamma-Aminobutyric acid SGS-742 Tezampanel Arbaclofen Arbaclofen Placarbil Sodium oxybate L-Baclofen
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Depression ( 33859377) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nasopharyngeal carcinoma ( 19664746) Nicotine dependence ( 28440896) Platelet count ( 26805783) Schizophrenia ( 27922604) Subcortical volume (MOSTest) ( 32665545) Ulna and radius bone mineral density ( 30172743) White blood cell count ( 27863252)	Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: ATF5 BDKRB1 CCR8 CHFR CPEB2 DRD2 GABBR2 GNAO1 GPR37 JAKMIP1 KCNJ6 MAX NSF RGS4 SMO YWHAZ	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		2550	2861
HPRD ID		04644	03992
Ensembl ID		ENSG00000204681	ENSG00000170775
Uniprot IDs		A0A0G2JKF9 A0A1U9X7R0 C9J342 Q59HG8 Q5SUJ9 Q8IW08 Q9UBS5	O15354
PDB IDs		4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6HKC 6UO8 6UO9 6UOA 6VJM 6W2X 6W2Y 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dopamine Receptor Signaling Pathway Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neural Precursor Cell Proliferation GABA-ergic Synapse G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Transport Peptide Binding G-protein Alpha-subunit Binding Dopamine Metabolic Process Positive Regulation Of Neuroblast Proliferation Ionotropic Glutamate Receptor Binding Response To Amphetamine Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organism Growth Regulation Of Monoatomic Ion Transport Negative Regulation Of Blood Pressure Response To Amine Negative Regulation Of Insulin Secretion Regulation Of Neuroblast Proliferation Response To Cocaine Catecholamine Metabolic Process Regulation Of Heart Contraction Neuroblast Proliferation Negative Regulation Of Peptide Secretion Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Protein Sequestering Activity Ventral Midline Determination Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Protein Localization Regulation Of Biological Quality Ciliary Membrane Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Bradykinin Receptor Activity Regulation Of Blood Circulation Negative Regulation Of Hormone Secretion Biogenic Amine Metabolic Process Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Response To Alcohol Mu-type Opioid Receptor Binding Prosaposin Receptor Activity	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion
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