GABBR1 and JAKMIP1

Number of citations of the paper that reports this interaction (PMID 14718537)
9

Data Source:
HPRD (in vitro)

		GABBR1	JAKMIP1
Gene Name		gamma-aminobutyric acid (GABA) B receptor, 1	janus kinase and microtubule interacting protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite G-protein Coupled Receptor Heterodimeric Complex Presynaptic Membrane Postsynaptic Membrane	Cytoplasm Microtubule Extrinsic Component Of Membrane Ribonucleoprotein Complex
	Molecular Function	G-protein Coupled GABA Receptor Activity Protein Binding	RNA Binding Protein Binding Microtubule Binding Kinesin Binding Kinase Binding GABA Receptor Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission	Protein Transport Cognition
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Inwardly rectifying K+ channels GABA B receptor activation Signaling by GPCR GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Metabolic disorders of biological oxidation enzymes GPCR ligand binding G protein gated Potassium channels Class C/3 (Metabotropic glutamate/pheromone receptors) GPCR downstream signaling G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs		Baclofen Progabide Vigabatrin
Diseases
GWAS		Crohn's disease ( 22412388) Nasopharyngeal carcinoma ( 19664746)	Response to angiotensin II receptor blocker therapy ( 22566498)
Protein-Protein Interactions		11 interactors: ATF5 CHFR GABBR2 GNAO1 JAKMIP1 KCNJ6 MAX NSF RGS4 UBC YWHAZ	4 interactors: GABBR1 JAK1 TYK2 YWHAG
Entrez ID		2550	152789
HPRD ID		04644	11292
Ensembl ID		ENSG00000204681	ENSG00000152969
Uniprot IDs		Q5SUJ9 Q8IW08 Q9UBS5	B4DHZ8 Q96N16
PDB IDs
Enriched GO Terms of Interacting Partners?			Peptidyl-tyrosine Autophosphorylation Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Protein Autophosphorylation Interleukin-2-mediated Signaling Pathway Regulation Of Innate Immune Response Peptidyl-tyrosine Phosphorylation Response To Interleukin-2 Intracellular Signal Transduction Cellular Response To Organic Substance Cytokine-mediated Signaling Pathway Signal Transduction Signaling Cellular Response To Cytokine Stimulus Cell Communication Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Regulation Of Response To Interferon-gamma Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Gamma-aminobutyric Acid Signaling Pathway Response To Cytokine Negative Regulation Of CAMP Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Cellular Response To Stimulus Negative Regulation Of Catalytic Activity Negative Regulation Of Nucleotide Metabolic Process Innate Immune Response Cell Migration Regulation Of Immune Response Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Cell Surface Receptor Signaling Pathway Peptidyl-amino Acid Modification Regulation Of Adenylate Cyclase Activity Positive Regulation Of Mitochondrion Organization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Antibiotic Cell Differentiation Regulation Of Cyclase Activity Response To Stimulus
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