SMO and HMGN4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SMO	HMGN4
Description		smoothened, frizzled class receptor	high mobility group nucleosomal binding domain 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Plasma Membrane Caveola Cilium Membrane Dendrite Endocytic Vesicle Membrane Cell Projection Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium Plasma Membrane Bounded Cell Projection	Chromatin Nucleus
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Patched Binding Protein Binding Oxysterol Binding Protein Kinase A Catalytic Subunit Binding Protein Sequestering Activity	DNA Binding Chromatin Binding Protein Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Negative Regulation Of Protein Phosphorylation Hair Follicle Development Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Heart Morphogenesis Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development Protein Import Into Nucleus Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Determination Of Left/right Symmetry Ventral Midline Determination Pattern Specification Process Neuroblast Proliferation Central Nervous System Development Midgut Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Tissue Development Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Spinal Cord Dorsal/ventral Patterning Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Cell Development Digestive Tract Development Embryonic Organ Development Developmental Growth Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Response To Inositol Regulation Of Somatic Stem Cell Population Maintenance Regulation Of Heart Morphogenesis	Chromatin Organization
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO
Drugs		Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib
Diseases		Basal cell carcinoma
GWAS		Osteoarthritis (hip) ( 30374069)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Small cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		28 interacting genes: ARLN ARV1 C18orf32 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS	8 interacting genes: CEBPA EWSR1 HPF1 PARP1 SMO TERF1 TERF2 TERF2IP
Entrez ID		6608	10473
HPRD ID		03294	17111
Ensembl ID		ENSG00000128602	ENSG00000182952
Uniprot IDs		Q99835	O00479
PDB IDs		4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM 7ZI0
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Heme Oxidation Heme Oxygenase (decyclizing) Activity Hedgehog Family Protein Binding Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Dorsal/ventral Neural Tube Patterning Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Cell Fate Specification Magnesium Ion Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction	Negative Regulation Of Telomere Maintenance Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Negative Regulation Of Chromosome Organization Telomere Maintenance Protein Localization To Chromosome Regulation Of Telomere Maintenance RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Protein Localization To Organelle Telomerase Activity Protection From Non-homologous End Joining At Telomere Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Chromosome Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding DNA Metabolic Process DNA Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Nuclear Body Nucleobase-containing Compound Biosynthetic Process Telomere Maintenance In Response To DNA Damage Protein Poly-ADP-ribosylation Regulation Of DNA Recombination Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair-dependent Chromatin Remodeling Nucleic Acid Metabolic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?