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SMO and RPN2
Number of citations of the paper that reports this interaction (PubMedID
28298427
)
90
Data Source:
BioGRID
(two hybrid)
SMO
RPN2
Description
smoothened, frizzled class receptor
ribophorin II
Image
GO Annotations
Cellular Component
Cytoplasm
Late Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Golgi Apparatus
Centriole
Plasma Membrane
Caveola
Cilium
Membrane
Dendrite
Endocytic Vesicle Membrane
Cell Projection
Ciliary Membrane
Extracellular Exosome
Ciliary Tip
9+0 Non-motile Cilium
Plasma Membrane Bounded Cell Projection
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Oligosaccharyltransferase Complex
Membrane
Nuclear Body
Oligosaccharyltransferase Complex A
Oligosaccharyltransferase Complex B
Molecular Function
CAMP-dependent Protein Kinase Inhibitor Activity
Transmembrane Signaling Receptor Activity
G Protein-coupled Receptor Activity
Patched Binding
Protein Binding
Oxysterol Binding
Protein Kinase A Catalytic Subunit Binding
Protein Sequestering Activity
Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ossification
Vasculogenesis
Osteoblast Differentiation
In Utero Embryonic Development
Cell Fate Specification
Neural Crest Cell Migration
Negative Regulation Of Protein Phosphorylation
Hair Follicle Development
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Heart Morphogenesis
Determination Of Left/right Asymmetry In Lateral Mesoderm
Type B Pancreatic Cell Development
Protein Import Into Nucleus
Apoptotic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Smoothened Signaling Pathway
Determination Of Left/right Symmetry
Ventral Midline Determination
Pattern Specification Process
Neuroblast Proliferation
Central Nervous System Development
Midgut Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Tissue Development
Anterior/posterior Pattern Specification
Dorsal/ventral Pattern Formation
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Spinal Cord Dorsal/ventral Patterning
Dentate Gyrus Development
Cerebellar Cortex Morphogenesis
Thalamus Development
Dorsal/ventral Neural Tube Patterning
Central Nervous System Neuron Differentiation
Cerebral Cortex Development
Positive Regulation Of Cell Migration
Epithelial Cell Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Hair Follicle Morphogenesis
Protein Localization To Nucleus
Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Protein Import Into Nucleus
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Positive Regulation Of Smoothened Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Organ Growth
Astrocyte Activation
Cell Development
Digestive Tract Development
Embryonic Organ Development
Developmental Growth
Skeletal Muscle Fiber Development
Smooth Muscle Tissue Development
Forebrain Morphogenesis
Homeostasis Of Number Of Cells Within A Tissue
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Protein Stabilization
Myoblast Migration
Negative Regulation Of Hair Follicle Development
Contact Inhibition
Atrial Septum Morphogenesis
Mammary Gland Epithelial Cell Differentiation
Epithelial-mesenchymal Cell Signaling
Somite Development
Pancreas Morphogenesis
Left/right Axis Specification
Cellular Response To Cholesterol
Dopaminergic Neuron Differentiation
Commissural Neuron Axon Guidance
Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Response To Inositol
Regulation Of Somatic Stem Cell Population Maintenance
Regulation Of Heart Morphogenesis
Protein Glycosylation
Protein N-linked Glycosylation
Protein Modification Process
Pathways
Class B/2 (Secretin family receptors)
Hedgehog 'off' state
BBSome-mediated cargo-targeting to cilium
Hedgehog 'on' state
Activation of SMO
Activation of SMO
SRP-dependent cotranslational protein targeting to membrane
Asparagine N-linked glycosylation
Maturation of spike protein
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Fluocinonide
Halcinonide
Vismodegib
Sonidegib
Glasdegib
Diseases
Basal cell carcinoma
GWAS
Osteoarthritis (hip) (
30374069
)
Appendicular lean mass (
33097823
)
Height (
31562340
)
Hippocampal atrophy (
19668339
)
Initial pursuit acceleration in psychotic disorders (
29064472
)
Kawasaki disease (
33692975
)
Interacting Genes
28 interacting genes:
ARLN
ARV1
C18orf32
EMC10
FKBP8
GABARAPL2
GABBR1
HMGN4
HMOX1
HMOX2
ITGB1BP1
JPH3
LEPROT
NDFIP1
NEDD4
NGEF
NIPA1
PLPP7
PTCH1
PTCH2
RPN2
S1PR5
SLC41A3
SSPN
TIMMDC1
TMCC2
TSPAN7
WLS
17 interacting genes:
ADRM1
BCL2L13
EZH2
FBN3
ISG15
LINC00632
LTB4R2
NDRG1
NGFR
PDE4B
PTEN
RBBP4
RCHY1
RHOA
SLC22A2
SMO
WEE2-AS1
Entrez ID
6608
6185
HPRD ID
03294
01609
Ensembl ID
ENSG00000128602
ENSG00000118705
Uniprot IDs
Q99835
P04844
PDB IDs
4JKV
4N4W
4O9R
4QIM
4QIN
5L7D
5L7I
5V56
5V57
6OT0
6XBJ
6XBK
6XBL
6XBM
7ZI0
6S7O
6S7T
8B6L
8PN9
Enriched GO Terms of Interacting Partners
?
Endoplasmic Reticulum Membrane
Membrane
Endoplasmic Reticulum
Heme Oxidation
Heme Oxygenase (decyclizing) Activity
Hedgehog Family Protein Binding
Hedgehog Receptor Activity
Epidermal Cell Fate Specification
Smoothened Binding
Heme Catabolic Process
Porphyrin-containing Compound Catabolic Process
Dorsal/ventral Neural Tube Patterning
Magnesium Ion Transmembrane Transporter Activity
Magnesium Ion Transmembrane Transport
Cell Fate Specification
Magnesium Ion Transport
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Dendritic Spine
Negative Regulation Of Hair Follicle Development
Regulation Of Protein Modification Process
Negative Regulation Of Cell Size
Forebrain Morphogenesis
ESC/E(Z) Complex
Myelin Maintenance
Odontogenesis
Negative Regulation Of Cell Migration
Animal Organ Development
Regulation Of Cell Migration
Negative Regulation Of Signaling
Negative Regulation Of Signal Transduction
Negative Regulation Of Cell Motility
Regulation Of Cell Motility
Negative Regulation Of Cell Communication
Regulation Of Hair Cycle
Regulation Of Hair Follicle Development
Dentate Gyrus Development
Negative Regulation Of Locomotion
Regulation Of Locomotion
Central Nervous System Development
Hair Follicle Morphogenesis
Molecular Function Inhibitor Activity
Regulation Of Protein Phosphorylation
Gamma-tubulin Binding
Regulation Of Cell Population Proliferation
Positive Regulation Of Multicellular Organismal Process
Regulation Of Kidney Development
Negative Regulation Of Multicellular Organismal Process
Regulation Of Phosphorylation
Regulation Of Cell Development
Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
Mitotic Cleavage Furrow Formation
Hepatocyte Homeostasis
Homeostasis Of Number Of Cells
Hair Follicle Development
Negative Regulation Of Synaptic Vesicle Clustering
Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation
Ventral Midline Determination
Negative Regulation Of Epithelial Cell Differentiation
Positive Regulation Of Macromolecule Metabolic Process
Apoptotic Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Phosphorus Metabolic Process
Rho Protein Signal Transduction
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Cell-substrate Adhesion
Aortic Valve Formation
Regulation Of Focal Adhesion Assembly
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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