SMO and NEDD4

Number of citations of the paper that reports this interaction (PMID 23106887)
1

Data Source:
BioGRID (two hybrid)

		SMO	NEDD4
Gene Name		smoothened, frizzled class receptor	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Integral Component Of Membrane Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium Ciliary Tip	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Apicolateral Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Activity Patched Binding Protein Binding Drug Binding Wnt-protein Binding Wnt-activated Receptor Activity	Protein Binding Ligase Activity Sodium Channel Inhibitor Activity Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ubiquitin Binding Phosphoserine Binding Phosphothreonine Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development G-protein Coupled Receptor Signaling Pathway Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Ventral Midline Determination Midgut Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Central Nervous System Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Skeletal Muscle Fiber Development Forebrain Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Canonical Wnt Signaling Pathway Detection Of Cell Density By Contact Stimulus Involved In Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Cellular Response To Cholesterol Renal System Development Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Maintenance Regulation Of Heart Morphogenesis	Adaptive Immune Response Outflow Tract Morphogenesis Endocardial Cushion Development Protein Monoubiquitination Protein Targeting To Lysosome Lysosomal Transport Neuromuscular Junction Development Negative Regulation Of Sodium Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination Transmission Of Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV Regulation Of Ion Transmembrane Transport T Cell Activation Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Glucocorticoid Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Development Involved In Symbiotic Interaction Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nucleocytoplasmic Transport Blood Vessel Morphogenesis Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Hedgehog 'off' state Assembly of the primary cilium GPCR ligand binding Metabolic disorders of biological oxidation enzymes BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors) Activation of SMO	Downregulation of ERBB4 signaling Antigen processing: Ubiquitination & Proteasome degradation ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Adaptive Immune System
Drugs
Diseases
GWAS			Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 20062064) Keloid ( 20711176)
Protein-Protein Interactions		3 interactors: NEDD4 PTCH1 PTCH2	215 interactors: ABL1 ABL2 ADRB2 AKT3 AMOT AMOTL1 AMPD2 ANKRD13D ANXA13 AP1G2 ARID1A ARRDC1 ARRDC3 ASPSCR1 AURKC BAIAP2 BECN1 BMPR1A BRCA2 C11orf63 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CUEDC1 DAZAP2 DCUN1D1 DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EPHA5 EPRS EPS15 ERBB3 ERBB4 ERMN FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FYN GBA GRB10 GRIN2A GRK4 GRK7 HGS HMCES HNRNPK HNRNPL HNRNPU HNRNPUL1 IGF1R IRS1 JUN KCNAB1 KCNAB2 KIAA1598 KIFC3 LAPTM5 LATS1 LITAF LUC7L2 MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MTMR4 MYCN N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NSRP1 NTRK1 NUDT21 PARP16 PDGFRB PKN2 PLK1 PLK2 PMEPA1 POLR2A POLR2B POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRRG1 PRRG2 PSMD4 PTEN RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RFT1 RNF11 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUVBL1 SAAL1 SAMSN1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEPT9 SFTPC SGK1 SGK2 SH3KBP1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 SULF1 SYK SYT1 TAF1B TBC1D7 TBK1 TCEANC TCP11L1 TEAD2 THRAP3 TNIK TOM1 TOM1L2 TP73 TRIM44 TRIM52 TRPV6 TSTA3 TTYH2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2M UBOX5 URI1 WBP1 WBP2 WEE1 WIBG YES1 YOD1
Entrez ID		6608	4734
HPRD ID		03294	03786
Ensembl ID		ENSG00000128602	ENSG00000069869
Uniprot IDs		A4D1K5 Q99835	P46934
PDB IDs		4JKV	2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Signaling Neural Plate Axis Specification Response To Chlorate Heart Morphogenesis Epidermis Development Tissue Development Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Protein Targeting Glucocorticoid Receptor Signaling Pathway Cell Proliferation Involved In Metanephros Development Response To Inorganic Substance Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Heart Development Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Keratinocyte Proliferation Cell Proliferation Involved In Kidney Development Regulation Of Signal Transduction Cellular Response To Cholesterol Protein Localization To Lysosome Neural Plate Development Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Regulation Of Signaling Negative Regulation Of Multicellular Organism Growth Receptor Catabolic Process Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Pharyngeal System Development Response To Cholesterol Protein Targeting To Vacuole Positive Regulation Of Transport Regulation Of Cholesterol Efflux Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Vacuole Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cardiovascular System Development Protein K63-linked Ubiquitination Intracellular Protein Transport Dorsal/ventral Neural Tube Patterning	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Phosphorylation Response To Growth Factor Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Cell Communication Cellular Protein Modification Process Regulation Of Phosphorylation Signal Transduction Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Death Regulation Of Metabolic Process Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Cellular Component Organization Regulation Of Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Cellular Metabolic Process Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification
Tagcloud ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smoothened sonic u373mg u87mg verify warrants wox1 wtp53 ww wwox zerumbone	accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins ww
Tagcloud (Difference) ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smoothened sonic u373mg u87mg verify warrants wox1 wtp53 wwox zerumbone	accepted colocalization colocalized conjugating cooperation cysteine cytoplasm deleted e2 e6ap enabled hect ligase neural neurites perinuclear periphery simultaneous specificities transfer ubc4 ubch5b ubch5c ubch6 ubch7 ubiquitin ubiquitination ubiquitins
Tagcloud (Intersection) ?		ww