GABBR1 and NSF

Number of citations of the paper that reports this interaction (PubMedID 16724110)
49

Data Source:
HPRD (in vivo)

		GABBR1	NSF
Description		gamma-aminobutyric acid type B receptor subunit 1	N-ethylmaleimide sensitive factor, vesicle fusing ATPase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Membrane Dendrite Axolemma Mitochondrial Membrane G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Heterodimeric Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Synapse Postsynaptic Membrane Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse GABA Receptor Complex G Protein-coupled GABA Receptor Complex	Cytoplasm Lysosomal Membrane Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Dendritic Shaft GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Extracellular Matrix Protein Binding	SNARE Binding Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Syntaxin-1 Binding Protein Kinase Binding Syntaxin Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Metal Ion Binding ATP-dependent Protein Disaggregase Activity
	Biological Process	Osteoblast Differentiation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Glutamate Secretion Positive Regulation Of Glutamate Secretion Negative Regulation Of Gamma-aminobutyric Acid Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Dopamine Secretion Response To Nicotine Response To Ethanol Negative Regulation Of Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Regulation Of Presynaptic Membrane Potential Neuron-glial Cell Signaling	Positive Regulation Of Receptor Recycling Potassium Ion Transport Intracellular Protein Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Regulation Of Exocytosis SNARE Complex Disassembly Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Positive Regulation Of Protein Catabolic Process
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs		Baclofen Acamprosate Progabide Taurine gamma-Aminobutyric acid SGS-742 Tezampanel Arbaclofen Arbaclofen Placarbil Sodium oxybate L-Baclofen	1-Ethyl-Pyrrolidine-2,5-Dione
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Depression ( 33859377) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nasopharyngeal carcinoma ( 19664746) Nicotine dependence ( 28440896) Platelet count ( 26805783) Schizophrenia ( 27922604) Subcortical volume (MOSTest) ( 32665545) Ulna and radius bone mineral density ( 30172743) White blood cell count ( 27863252)	Alcohol use disorder (total score) ( 30336701) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical surface area (global PC1) ( 32198502) Cortical volume ( 32963231) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30054594) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Parkinson's disease ( 21812969 19915575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Reaction time ( 29844566) Refractive error ( 32231278) Sense of smell ( 26632684) Thyroid stimulating hormone levels ( 30367059)
Interacting Genes		16 interacting genes: ATF5 BDKRB1 CCR8 CHFR CPEB2 DRD2 GABBR2 GNAO1 GPR37 JAKMIP1 KCNJ6 MAX NSF RGS4 SMO YWHAZ	31 interacting genes: ARRB1 ASPSCR1 CD28 CEP126 DRD2 EIF3E ERG28 ESR1 FILNC1 FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 LUC7L2 MEOX2 NAPA NAPG PLK2 PTPN9 RAMP3 RNF10 RPLP1 STX1A STX4 STX8 USO1 VAPA
Entrez ID		2550	4905
HPRD ID		04644	03380
Ensembl ID		ENSG00000204681	ENSG00000073969
Uniprot IDs		A0A0G2JKF9 A0A1U9X7R0 C9J342 Q59HG8 Q5SUJ9 Q8IW08 Q9UBS5	A0A384MTI6 P46459
PDB IDs		4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6HKC 6UO8 6UO9 6UOA 6VJM 6W2X 6W2Y 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2	6KZQ
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dopamine Receptor Signaling Pathway Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neural Precursor Cell Proliferation GABA-ergic Synapse G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Transport Peptide Binding G-protein Alpha-subunit Binding Dopamine Metabolic Process Positive Regulation Of Neuroblast Proliferation Ionotropic Glutamate Receptor Binding Response To Amphetamine Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organism Growth Regulation Of Monoatomic Ion Transport Negative Regulation Of Blood Pressure Response To Amine Negative Regulation Of Insulin Secretion Regulation Of Neuroblast Proliferation Response To Cocaine Catecholamine Metabolic Process Regulation Of Heart Contraction Neuroblast Proliferation Negative Regulation Of Peptide Secretion Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Protein Sequestering Activity Ventral Midline Determination Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Protein Localization Regulation Of Biological Quality Ciliary Membrane Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Bradykinin Receptor Activity Regulation Of Blood Circulation Negative Regulation Of Hormone Secretion Biogenic Amine Metabolic Process Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Response To Alcohol Mu-type Opioid Receptor Binding Prosaposin Receptor Activity	Membrane Fusion SNARE Complex Intracellular Protein Localization SNARE Binding Protein Transport Organelle Localization By Membrane Tethering Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Membrane Docking SNAP Receptor Activity Vesicle Fusion Establishment Of Protein Localization Chemical Synaptic Transmission Organelle Membrane Fusion Trans-synaptic Signaling Synaptic Signaling G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Organelle Fusion Intracellular Protein Transport Vesicle Docking Positive Regulation Of Synaptic Transmission Dendritic Spine Regulation Of Protein Localization To Cell Periphery GABA Receptor Complex Golgi Vesicle Transport Soluble NSF Attachment Protein Activity Regulation Of Protein Localization To Membrane Membrane Organization Negative Regulation Of Dopamine Secretion Vesicle Organization Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Modulation Of Chemical Synaptic Transmission Intracellular Transport Regulation Of Postsynaptic Membrane Potential Neuron-glial Cell Signaling Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Establishment Of Localization In Cell GABA Receptor Activity AMPA Glutamate Receptor Activity Postsynaptic Membrane Regulation Of Protein Localization To Plasma Membrane ATP-dependent Protein Binding Chloride Channel Inhibitor Activity Synaptic Transmission, Glutamatergic Cell-cell Signaling Syntaxin Binding Endomembrane System
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