GABBR1 and KCNJ6

Number of citations of the paper that reports this interaction (PMID 17185339)
30

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GABBR1	KCNJ6
Gene Name		gamma-aminobutyric acid (GABA) B receptor, 1	potassium channel, inwardly rectifying subfamily J, member 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite G-protein Coupled Receptor Heterodimeric Complex Presynaptic Membrane Postsynaptic Membrane	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	G-protein Coupled GABA Receptor Activity Protein Binding	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Ion Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Inwardly rectifying K+ channels GABA B receptor activation Signaling by GPCR GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Metabolic disorders of biological oxidation enzymes GPCR ligand binding G protein gated Potassium channels Class C/3 (Metabotropic glutamate/pheromone receptors) GPCR downstream signaling G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs		Baclofen Progabide Vigabatrin	Halothane
Diseases
GWAS		Crohn's disease ( 22412388) Nasopharyngeal carcinoma ( 19664746)	Electroencephalographic traits in alcoholism ( 22554406)
Protein-Protein Interactions		11 interactors: ATF5 CHFR GABBR2 GNAO1 JAKMIP1 KCNJ6 MAX NSF RGS4 UBC YWHAZ	7 interactors: ADRB2 BIRC5 DLG1 DRD2 GABBR1 KCNJ3 KCNJ9
Entrez ID		2550	3763
HPRD ID		04644	02929
Ensembl ID		ENSG00000204681
Uniprot IDs		Q5SUJ9 Q8IW08 Q9UBS5	P48051
PDB IDs
Enriched GO Terms of Interacting Partners?			Synaptic Transmission Regulation Of Ion Transport Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Cell-cell Signaling Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Peristalsis Regulation Of Ion Transmembrane Transport Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Potassium Ion Import Temperature Homeostasis Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Protein Kinase B Signaling Activation Of Protein Kinase Activity Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Blood Pressure Smooth Muscle Contraction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Potassium Ion Transport Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase B Signaling Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Type B Pancreatic Cell Proliferation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Cell Division Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cell Communication Negative Regulation Of Dopamine Secretion Positive Regulation Of Exit From Mitosis
Tagcloud ?			channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcna1 kcnd2 kcnj3 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant
Tagcloud (Difference) ?			channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcna1 kcnd2 kcnj3 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant
Tagcloud (Intersection) ?