SMO and NDFIP1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SMO	NDFIP1
Description		smoothened, frizzled class receptor	Nedd4 family interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Plasma Membrane Caveola Cilium Membrane Dendrite Endocytic Vesicle Membrane Cell Projection Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium Plasma Membrane Bounded Cell Projection	Golgi Membrane Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cell Cortex Endosome Membrane Membrane Dendrite Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Patched Binding Protein Binding Oxysterol Binding Protein Kinase A Catalytic Subunit Binding Protein Sequestering Activity	Protein Binding WW Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Negative Regulation Of Protein Phosphorylation Hair Follicle Development Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Heart Morphogenesis Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development Protein Import Into Nucleus Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Determination Of Left/right Symmetry Ventral Midline Determination Pattern Specification Process Neuroblast Proliferation Central Nervous System Development Midgut Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Tissue Development Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Spinal Cord Dorsal/ventral Patterning Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Cell Development Digestive Tract Development Embryonic Organ Development Developmental Growth Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Response To Inositol Regulation Of Somatic Stem Cell Population Maintenance Regulation Of Heart Morphogenesis	Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Type 2 Immune Response Ubiquitin-dependent Protein Catabolic Process Intracellular Iron Ion Homeostasis Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Negative Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Negative Regulation Of Protein Transport Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO
Drugs		Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib
Diseases		Basal cell carcinoma
GWAS		Osteoarthritis (hip) ( 30374069)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 34103634 32296059 31959851 31619474 31361310 29273806 22561531 27182965) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte count ( 27863252) HDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Low susceptibility to hepatitis C infection ( 31206233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088 31604244 24076602) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Physiological traits ( 31902109) Platelet count ( 27863252 32888494 29403010) Plateletcrit ( 27863252 32888494) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ARLN ARV1 C18orf32 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS	10 interacting genes: BDKRB1 CCR2 ITCH NEDD4 NTRK2 PTEN SMO UQCRH WEE2-AS1 WWP2
Entrez ID		6608	80762
HPRD ID		03294	14816
Ensembl ID		ENSG00000128602	ENSG00000131507
Uniprot IDs		Q99835	Q9BT67
PDB IDs		4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM 7ZI0
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Heme Oxidation Heme Oxygenase (decyclizing) Activity Hedgehog Family Protein Binding Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Dorsal/ventral Neural Tube Patterning Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Cell Fate Specification Magnesium Ion Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction	Protein K63-linked Ubiquitination Potassium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Forebrain Morphogenesis Regulation Of Potassium Ion Export Across Plasma Membrane Cell Migration Negative Regulation Of Transport Regulation Of Anatomical Structure Morphogenesis Regulation Of Membrane Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Transport Dentate Gyrus Development Regulation Of Biological Quality Negative Regulation Of Potassium Ion Transport Cell Motility Homeostasis Of Number Of Cells Within A Tissue Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Activity Regulation Of Growth Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Receptor Internalization Positive Regulation Of Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Channel Inhibitor Activity Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Potassium Ion Transport Regulation Of Signaling Ubiquitin-protein Transferase Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Protein Metabolic Process Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Regulation Of Developmental Process Brain-derived Neurotrophic Factor Receptor Activity Cerebral Cortex Development Regulation Of Cell Development Vasculogenesis Regulation Of Neurogenesis Regulation Of Cell Differentiation Negative Regulation Of Synaptic Vesicle Clustering
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