GABBR1 and RGS4

Number of citations of the paper that reports this interaction (PMID 17185339)
30

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GABBR1	RGS4
Gene Name		gamma-aminobutyric acid (GABA) B receptor, 1	regulator of G-protein signaling 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite G-protein Coupled Receptor Heterodimeric Complex Presynaptic Membrane Postsynaptic Membrane	Cytoplasm Cytosol Plasma Membrane Protein Complex
	Molecular Function	G-protein Coupled GABA Receptor Activity Protein Binding	G-protein Alpha-subunit Binding GTPase Activator Activity Calmodulin Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission	Inactivation Of MAPK Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Inwardly rectifying K+ channels GABA B receptor activation Signaling by GPCR GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Metabolic disorders of biological oxidation enzymes GPCR ligand binding G protein gated Potassium channels Class C/3 (Metabotropic glutamate/pheromone receptors) GPCR downstream signaling G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	Signaling by GPCR GPCR downstream signaling G alpha (z) signalling events G alpha (i) signalling events
Drugs		Baclofen Progabide Vigabatrin
Diseases
GWAS		Crohn's disease ( 22412388) Nasopharyngeal carcinoma ( 19664746)
Protein-Protein Interactions		11 interactors: ATF5 CHFR GABBR2 GNAO1 JAKMIP1 KCNJ6 MAX NSF RGS4 UBC YWHAZ	12 interactors: CALM1 COPB1 COPB2 ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR
Entrez ID		2550	5999
HPRD ID		04644	03947
Ensembl ID		ENSG00000204681	ENSG00000117152
Uniprot IDs		Q5SUJ9 Q8IW08 Q9UBS5	P49798
PDB IDs
Enriched GO Terms of Interacting Partners?			Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Inositol Phosphate Metabolic Process Platelet Activation Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Cyclase Activity Synaptic Transmission Wound Healing Regulation Of CAMP Biosynthetic Process Signal Transduction Cell Activation Response To Wounding COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of CAMP Metabolic Process G-protein Coupled Acetylcholine Receptor Signaling Pathway Golgi Vesicle Budding Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Catalytic Activity Cell-cell Signaling Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Cellular Response To Stimulus Vesicle Targeting, To, From Or Within Golgi Regulation Of Calcium Ion Transport Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Organization Regulation Of Body Fluid Levels Retrograde Vesicle-mediated Transport, Golgi To ER Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Calcium Ion Transport Vesicle Targeting Localization Within Membrane Regulation Of Phosphorylation Activation Of Phospholipase C Activity Intra-Golgi Vesicle-mediated Transport Regulation Of Protein Kinase Activity Positive Regulation Of Phospholipase C Activity
Tagcloud ?			102kspsklsp109 adenylyl anandamide anticipated arrestin1 beta3 cb1 conform contraction endowed engage erk1 galphai galphaq gbetagamma gi grk5 k215r minigene mlc myosin mypt1 ptx rhoa rip ser103 ser108 signaled uncoupling
Tagcloud (Difference) ?			102kspsklsp109 adenylyl anandamide anticipated arrestin1 beta3 cb1 conform contraction endowed engage erk1 galphai galphaq gbetagamma gi grk5 k215r minigene mlc myosin mypt1 ptx rhoa rip ser103 ser108 signaled uncoupling
Tagcloud (Intersection) ?