GABBR1 and CCR8

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GABBR1	CCR8
Description		gamma-aminobutyric acid type B receptor subunit 1	C-C motif chemokine receptor 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Membrane Dendrite Axolemma Mitochondrial Membrane G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Heterodimeric Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Synapse Postsynaptic Membrane Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse GABA Receptor Complex G Protein-coupled GABA Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Extracellular Matrix Protein Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Osteoblast Differentiation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Glutamate Secretion Positive Regulation Of Glutamate Secretion Negative Regulation Of Gamma-aminobutyric Acid Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Dopamine Secretion Response To Nicotine Response To Ethanol Negative Regulation Of Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Regulation Of Presynaptic Membrane Potential Neuron-glial Cell Signaling	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Baclofen Acamprosate Progabide Taurine gamma-Aminobutyric acid SGS-742 Tezampanel Arbaclofen Arbaclofen Placarbil Sodium oxybate L-Baclofen
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Depression ( 33859377) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nasopharyngeal carcinoma ( 19664746) Nicotine dependence ( 28440896) Platelet count ( 26805783) Schizophrenia ( 27922604) Subcortical volume (MOSTest) ( 32665545) Ulna and radius bone mineral density ( 30172743) White blood cell count ( 27863252)	Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		16 interacting genes: ATF5 BDKRB1 CCR8 CHFR CPEB2 DRD2 GABBR2 GNAO1 GPR37 JAKMIP1 KCNJ6 MAX NSF RGS4 SMO YWHAZ	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		2550	1237
HPRD ID		04644	03497
Ensembl ID		ENSG00000204681	ENSG00000179934
Uniprot IDs		A0A0G2JKF9 A0A1U9X7R0 C9J342 Q59HG8 Q5SUJ9 Q8IW08 Q9UBS5	P51685
PDB IDs		4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6HKC 6UO8 6UO9 6UOA 6VJM 6W2X 6W2Y 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2	8KFX 8KFY 8KFZ 8TLM 8U1U 8XML
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dopamine Receptor Signaling Pathway Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neural Precursor Cell Proliferation GABA-ergic Synapse G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Transport Peptide Binding G-protein Alpha-subunit Binding Dopamine Metabolic Process Positive Regulation Of Neuroblast Proliferation Ionotropic Glutamate Receptor Binding Response To Amphetamine Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organism Growth Regulation Of Monoatomic Ion Transport Negative Regulation Of Blood Pressure Response To Amine Negative Regulation Of Insulin Secretion Regulation Of Neuroblast Proliferation Response To Cocaine Catecholamine Metabolic Process Regulation Of Heart Contraction Neuroblast Proliferation Negative Regulation Of Peptide Secretion Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Protein Sequestering Activity Ventral Midline Determination Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Protein Localization Regulation Of Biological Quality Ciliary Membrane Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Bradykinin Receptor Activity Regulation Of Blood Circulation Negative Regulation Of Hormone Secretion Biogenic Amine Metabolic Process Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Response To Alcohol Mu-type Opioid Receptor Binding Prosaposin Receptor Activity	Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex
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