SMO and SSPN

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SMO	SSPN
Description		smoothened, frizzled class receptor	sarcospan
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Plasma Membrane Caveola Cilium Membrane Dendrite Endocytic Vesicle Membrane Cell Projection Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium Plasma Membrane Bounded Cell Projection	Golgi Membrane Plasma Membrane Dystrophin-associated Glycoprotein Complex Membrane Transport Vesicle Sarcolemma Synapse Postsynaptic Membrane
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Patched Binding Protein Binding Oxysterol Binding Protein Kinase A Catalytic Subunit Binding Protein Sequestering Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Negative Regulation Of Protein Phosphorylation Hair Follicle Development Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Heart Morphogenesis Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development Protein Import Into Nucleus Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Determination Of Left/right Symmetry Ventral Midline Determination Pattern Specification Process Neuroblast Proliferation Central Nervous System Development Midgut Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Tissue Development Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Spinal Cord Dorsal/ventral Patterning Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Cell Development Digestive Tract Development Embryonic Organ Development Developmental Growth Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Response To Inositol Regulation Of Somatic Stem Cell Population Maintenance Regulation Of Heart Morphogenesis	Muscle Contraction Cell Adhesion
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib
Diseases		Basal cell carcinoma
GWAS		Osteoarthritis (hip) ( 30374069)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Atrial fibrillation ( 30061737 29892015) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Lymphocyte count ( 32888494) Male-pattern baldness ( 28196072 29146897 27182965) PR interval ( 32439900) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ARLN ARV1 C18orf32 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS	2 interacting genes: SGCG SMO
Entrez ID		6608	8082
HPRD ID		03294	03359
Ensembl ID		ENSG00000128602	ENSG00000123096
Uniprot IDs		Q99835	Q14714
PDB IDs		4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM 7ZI0
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Heme Oxidation Heme Oxygenase (decyclizing) Activity Hedgehog Family Protein Binding Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Dorsal/ventral Neural Tube Patterning Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Cell Fate Specification Magnesium Ion Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction	Muscle Tissue Development Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination Gene Expression Dystroglycan Complex Contact Inhibition Cerebellar Cortex Morphogenesis Detection Of Cell Density Epithelial-mesenchymal Cell Signaling Pancreas Morphogenesis Response To Inositol Negative Regulation Of Hair Follicle Development Sarcoglycan Complex Tissue Development Determination Of Left/right Asymmetry In Lateral Mesoderm Commissural Neuron Axon Guidance Thalamus Development Cellular Response To Cholesterol Spinal Cord Dorsal/ventral Patterning Somite Development CAMP-dependent Protein Kinase Inhibitor Activity Midgut Development Regulation Of Somatic Stem Cell Population Maintenance Mesenchymal To Epithelial Transition Myoblast Migration Left/right Axis Specification Atrial Septum Morphogenesis Dorsal/ventral Neural Tube Patterning Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Patched Binding 9+0 Non-motile Cilium Oxysterol Binding Protein Kinase A Catalytic Subunit Binding Forebrain Morphogenesis Regulation Of Heart Morphogenesis Type B Pancreatic Cell Development Mammary Gland Epithelial Cell Differentiation Negative Regulation Of DNA Binding Astrocyte Activation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Cellular Response To Sterol Regulation Of Hair Follicle Development Smooth Muscle Tissue Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Heart Contraction Regulation Of Hair Cycle Dentate Gyrus Development Response To Cholesterol Plasma Membrane Bounded Cell Projection Skeletal Muscle Fiber Development
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