GABBR1

Description		gamma-aminobutyric acid type B receptor subunit 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Membrane Dendrite Axolemma Mitochondrial Membrane G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Heterodimeric Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Synapse Postsynaptic Membrane Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse GABA Receptor Complex G Protein-coupled GABA Receptor Complex
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Extracellular Matrix Protein Binding
	Biological Process	Osteoblast Differentiation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Glutamate Secretion Positive Regulation Of Glutamate Secretion Negative Regulation Of Gamma-aminobutyric Acid Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Dopamine Secretion Response To Nicotine Response To Ethanol Negative Regulation Of Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Regulation Of Presynaptic Membrane Potential Neuron-glial Cell Signaling
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Baclofen Acamprosate Progabide Taurine gamma-Aminobutyric acid SGS-742 Tezampanel Arbaclofen Arbaclofen Placarbil Sodium oxybate L-Baclofen
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Depression ( 33859377) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nasopharyngeal carcinoma ( 19664746) Nicotine dependence ( 28440896) Platelet count ( 26805783) Schizophrenia ( 27922604) Subcortical volume (MOSTest) ( 32665545) Ulna and radius bone mineral density ( 30172743) White blood cell count ( 27863252)
Interacting Genes		16 interacting genes: ATF5 BDKRB1 CCR8 CHFR CPEB2 DRD2 GABBR2 GNAO1 GPR37 JAKMIP1 KCNJ6 MAX NSF RGS4 SMO YWHAZ
Entrez ID		2550
HPRD ID		04644
Ensembl ID		ENSG00000204681
Uniprot IDs		A0A0G2JKF9 A0A1U9X7R0 C9J342 Q59HG8 Q5SUJ9 Q8IW08 Q9UBS5
PDB IDs		4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6HKC 6UO8 6UO9 6UOA 6VJM 6W2X 6W2Y 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Dopamine Receptor Signaling Pathway Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neural Precursor Cell Proliferation GABA-ergic Synapse G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Transport Peptide Binding G-protein Alpha-subunit Binding Dopamine Metabolic Process Positive Regulation Of Neuroblast Proliferation Ionotropic Glutamate Receptor Binding Response To Amphetamine Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organism Growth Regulation Of Monoatomic Ion Transport Negative Regulation Of Blood Pressure Response To Amine Negative Regulation Of Insulin Secretion Regulation Of Neuroblast Proliferation Response To Cocaine Catecholamine Metabolic Process Regulation Of Heart Contraction Neuroblast Proliferation Negative Regulation Of Peptide Secretion Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Protein Sequestering Activity Ventral Midline Determination Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Protein Localization Regulation Of Biological Quality Ciliary Membrane Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Bradykinin Receptor Activity Regulation Of Blood Circulation Negative Regulation Of Hormone Secretion Biogenic Amine Metabolic Process Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Response To Alcohol Mu-type Opioid Receptor Binding Prosaposin Receptor Activity
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