SMO and PTCH2

Number of citations of the paper that reports this interaction (PMID 9811851)
27

Data Source:
HPRD (in vivo)

		SMO	PTCH2
Gene Name		smoothened, frizzled class receptor	patched 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Integral Component Of Membrane Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium Ciliary Tip	Integral Component Of Membrane
	Molecular Function	G-protein Coupled Receptor Activity Patched Binding Protein Binding Drug Binding Wnt-protein Binding Wnt-activated Receptor Activity	Smoothened Binding Hedgehog Receptor Activity Hedgehog Family Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development G-protein Coupled Receptor Signaling Pathway Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Ventral Midline Determination Midgut Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Central Nervous System Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Skeletal Muscle Fiber Development Forebrain Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Canonical Wnt Signaling Pathway Detection Of Cell Density By Contact Stimulus Involved In Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Cellular Response To Cholesterol Renal System Development Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Maintenance Regulation Of Heart Morphogenesis	Signal Transduction Epidermis Development Hair Cycle Negative Regulation Of Smoothened Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Hedgehog 'off' state Assembly of the primary cilium GPCR ligand binding Metabolic disorders of biological oxidation enzymes BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors) Activation of SMO	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: NEDD4 PTCH1 PTCH2	4 interactors: DHH IHH SHH SMO
Entrez ID		6608	8643
HPRD ID		03294	04722
Ensembl ID		ENSG00000128602	ENSG00000117425
Uniprot IDs		A4D1K5 Q99835	Q9Y6C5
PDB IDs		4JKV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Signaling Neural Plate Axis Specification Response To Chlorate Heart Morphogenesis Epidermis Development Tissue Development Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Protein Targeting Glucocorticoid Receptor Signaling Pathway Cell Proliferation Involved In Metanephros Development Response To Inorganic Substance Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Heart Development Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Keratinocyte Proliferation Cell Proliferation Involved In Kidney Development Regulation Of Signal Transduction Cellular Response To Cholesterol Protein Localization To Lysosome Neural Plate Development Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Regulation Of Signaling Negative Regulation Of Multicellular Organism Growth Receptor Catabolic Process Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Pharyngeal System Development Response To Cholesterol Protein Targeting To Vacuole Positive Regulation Of Transport Regulation Of Cholesterol Efflux Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Vacuole Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cardiovascular System Development Protein K63-linked Ubiquitination Intracellular Protein Transport Dorsal/ventral Neural Tube Patterning	Intein-mediated Protein Splicing Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Smoothened Signaling Pathway Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Hh Target Transcription Factor Activity Embryonic Heart Tube Development Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation Smoothened Signaling Pathway Determination Of Bilateral Symmetry Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Epithelial-mesenchymal Cell Signaling Digestive Tract Development Osteoblast Differentiation Digestive System Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Lateral Mesoderm Development Thalamus Development Negative Regulation Of Alpha-beta T Cell Differentiation Cell-cell Signaling Positive Regulation Of T Cell Differentiation In Thymus Heart Morphogenesis Negative Regulation Of Alpha-beta T Cell Activation Ossification Regulation Of Epithelial Cell Proliferation Positive Regulation Of Neuroblast Proliferation Embryonic Digestive Tract Morphogenesis Cell Fate Commitment Spinal Cord Dorsal/ventral Patterning Embryonic Organ Morphogenesis Regulation Of T Cell Differentiation In Thymus Spinal Cord Patterning Muscle Tissue Development Hair Follicle Morphogenesis Negative Regulation Of T Cell Differentiation Dorsal/ventral Neural Tube Patterning Positive Regulation Of Kidney Development
Tagcloud ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smoothened sonic u373mg u87mg verify warrants wox1 wtp53 ww wwox zerumbone	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smoothened sonic u373mg u87mg verify warrants wox1 wtp53 ww wwox zerumbone	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?