LSM10 and BMPR2

Number of citations of the paper that reports this interaction (PMID 15188402)
20

Data Source:
HPRD (in vitro)

		LSM10	BMPR2
Gene Name		LSM10, U7 small nuclear RNA associated	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm U7 SnRNP Cajal Body	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane
	Molecular Function	Protein Binding Histone Pre-mRNA DCP Binding	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription Histone MRNA Metabolic Process RNA Splicing Gene Expression MRNA 3'-end Processing Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process
Pathways		SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination SLBP independent Processing of Histone Pre-mRNAs	Signaling by BMP
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		6 interactors: BMPR2 CLNS1A LSM11 LSM3 SLBP SMN1	49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		84967	659
HPRD ID		14326	02880
Ensembl ID		ENSG00000181817	ENSG00000204217
Uniprot IDs		Q969L4	Q13873
PDB IDs			2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing Histone MRNA 3'-end Processing RNA Metabolic Process Gene Expression Histone MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Termination Of RNA Polymerase II Transcription Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process RNA Splicing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Termination Nitrogen Compound Metabolic Process MRNA 3'-end Processing RNA 3'-end Processing Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Vasoconstriction Ribonucleoprotein Complex Assembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Axon Extension Involved In Axon Guidance Lymphatic Endothelial Cell Differentiation Ribonucleoprotein Complex Biogenesis Lymphangiogenesis Lymph Vessel Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Venous Blood Vessel Development NcRNA Metabolic Process Retina Vasculature Development In Camera-type Eye Lymph Vessel Development Negative Regulation Of Systemic Arterial Blood Pressure Nuclear DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Cell Cycle G1/S Phase Transition Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cell Volume Homeostasis Activin Receptor Signaling Pathway Chondrocyte Development Positive Regulation Of BMP Signaling Pathway	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus
Tagcloud ?		altering analogous arrested captured chase coordinated elimination h2a h2b h3f3b hela hn hnrnp nonpolyadenylated nontransformed oligonucleotide posttranscriptional precisely replication repress restricts ribonucleoprotein rnp snrna snrnp spectrometric tightly u7 ul1	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Difference) ?		altering analogous arrested captured chase coordinated elimination h2a h2b h3f3b hela hn hnrnp nonpolyadenylated nontransformed oligonucleotide posttranscriptional precisely replication repress restricts ribonucleoprotein rnp snrna snrnp spectrometric tightly u7 ul1	apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Intersection) ?